醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷患者的临床疗效

Refreshing Static Injection Joint Naloxone Hydrochloride Injection Clinical Curative Effect for the Treatment of Patients with Cerebral Hemorrhage with Coma

目的研究醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷病患的临床疗效。方法整群选取该院2013年11月—2015年1月住院接受治疗的83例脑出血伴昏迷病患。病患分组方法:密封信封随机分组。83例病患分为组a和组b两个组别。组a 4 mg盐酸纳洛酮注射液+250 m L 5%葡萄糖静滴,1次/d,用药2周;组b 4 mg盐酸纳洛酮注射液+250 m L 5%葡萄糖静滴,20 m L醒脑静注射液+250 m L 5%葡萄糖静滴,均1天1次,用药2周。观察指标:1总有效率;2药物副作用;3用药前后病患神经功能缺损评分、认知评分、昏迷评分、血肿量的差异;4昏迷时间。结果组b总有效率95.24%相比于组a75.61%总有效率更高,神经功能缺损评分、认知评分、昏迷评分、血肿量改善更显著,差异有统计学意义P<0.05;所有病患无明显药物不良反应,差异有统计学意义P>0.05;组b昏迷时间(5.51±2.41)h比a(8.39±2.77)h更短,差异有统计学意义P<0.05。结论醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷病患的临床疗效确切,可有效促醒,减少血肿,改善病患认知功能和神经功能,安全性高,值得推广。

Objective Study of Xingnaojing injection combined with hydrochloride naloxone injection in the treatment of cerebral hemorrhage with coma patient clinical curative effect. Methods Group selection 83 cases of cerebral hemorrhage with coma patients admitted in our hospital from November 2013-2015 to January. Patient grouping method： random grouping of sealed envelopes. 83 patients were divided into group a and group b in two groups. Group a 4 mg naloxone hydrochloride injection ＋250 m L 5% glucose intravenous, 1 times 1 day, 2 weeks of medication; intravenous drip of group b4 mg naloxone hydrochloride injection ＋250 m L 5% glucose, 20 ml Xingnaojing injection ＋250 m L 5% glucose intravenous,1 day 1 times, medication 2 weeks. Observation index： ①the total effective rate; ②drug side effects; ③before and after the treatment of patients with neurological deficit scores, cognitive score, coma score, the difference between the amount of hematoma; ④ coma time. Results Group b total effective rate is 95.24% compared to a group a75.61% total efficiency is more high, neural function defect score, cognitive score, coma score, hematoma volume improved more significantly,the difference of the was statically significant P〈0.05; all patients without obvious side effects of drugs,P〉0.05; coma time in B group（5.51±2.41）h than a（8.39±2.77）h shorter, the difference of the was statically significant P〈0.05. Conclusion Xingnaojing injection hydrochloride combined with naloxone injection in the treatment of cerebral hemorrhage complicated with coma patient clinical curative effect, can effectively promote wake up, reduce hematoma, improve the cognitive function and neural function of the patient, high safety, worthy of promotion.