蛋白酪氨酸磷酸酶1B基因多态性与妊娠期高血压疾病的相关性研究

Study on the Relationship between 1B Gene Polymorphism and Hypertensive Disorder Complicating Pregnancy

目的测序妊娠期高血压疾病患者的蛋白酪氨酸磷酸酶1B基因多态性,探讨其与妊娠期高血压疾病的相关性。方法随机选取该院2013年6月—2015年12月收治的子痫前期患者、妊娠期高血压患者、正常妊娠孕妇及正常体检人员各50例作为研究对象,测序其蛋白酪氨酸磷酸酶1B基因的IVS6+G82A基因位点多态性,进行对比分析。结果子痫前期及妊娠期高血压患者GG基因型(40.00%、26.00%)以及G等位基因频率(62.00%、46.00%)显著高于正常妊娠(16.00%、40.00%)以及正常体检人员(14.00%、38.00%),P<0.05,差异有统计学意义。结论蛋白酪氨酸磷酸酶1B基因IVS6+G82A位点多态性与妊娠期高血压疾病的发生存在一定相关性。

Objective To investigate the polymorphism of protein tyrosine phosphatase 1B gene in patients with hypertensive disorder complicating pregnancy and to investigate its correlation with the disease of pregnancy induced hypertension.Methods 50 cases of patients from June 2013 to December 2015 with preeclampsia, pregnancy induced hypertension, normal pregnant women and normal physical examination personnel were selected as the research object, and the IVS6＋G82A gene polymorphism of 1B gene was sequenced. Results Preeclampsia and gestational hypertension GG genotype（40.00%,26.00%） and the G allele（62.00%, 46.00%） was significantly higher than in normal pregnancy（16.00%, 40.00%） as well as normal medical personnel [to the specific data]（14.00%, 38.00%）, P〈0.05, statistically significant. Conclusion The polymorphism of IVS6＋G82A gene 1B polymorphism in the protein tyrosine phosphatase is related to the occurrence of hypertension in pregnancy.