缺血性脑卒中后血管性痴呆危险因素

The Risk Factor Analysis of the Vascular Dementia after Ischemic Stroke

目的探讨缺血性脑卒中（IS）后发生血管性痴呆（VD）的危险因素。方法方便选取2011年1月—2015年12月该院收治的100例IS后VD患者作为观察组,选取IS后非VD患者124例作为对照组。对比两组患者的临床资料,采用χ^2检验,t检验进行IS后VD危险因素的单因素分析,采用多因素Logistic回归分析进行独立危险因素分析。结果观察组患者平均年龄（67.93±5.39）岁,对照组患者平均年龄（56.93±4.32）岁,观察组年龄显著高于对照组患者,差异有统计学意义（t=5.38,P〈0.05）。单因素分析结果显示：两组在年龄、合并高血压病、糖尿病、冠心病、吸烟史、脑卒中史、多发性脑梗死、梗死部位（额叶、颞叶及基底节）方面差异具有统计学意义（P〈0.05）;多因素Logistic回归分析结果显示：年龄、合并高血压、糖尿病、高脂血症、多发性脑梗死、梗死部位（额叶和基底节）是IS后VD发生的独立危险因素。结论高龄、合并高血压、糖尿病、高脂血症、多发性脑梗死、梗死部位（额叶和基底节）等均是影响IS后VD发生的危险因素,应加强对此类IS患者VD的早期防治。

Objective To investigate the risk factors of vascular dementia（VD） after the ischemic stroke（IS）. Methods Convenient selection selected 100 cases of VD patients after IS from January 2011- December 2015 as the observation group, selected 100 cases of non-VD after the IS patients as the control group. Compared the clinical data of the two groups of patients, using the chi-square test and t test to do the single factor analysis of risk factors, using multiariable Logistic regression analysis to do the independent risk factor analysis. Results Observation group of patients with an average age of（67.93±5.39） years old, The average age of the control group was（56.93± 4.32） years old, The age of observation group was significantly higher than that of control group, the difference was statically significant（t=5.38, P〈0.05）. Single factor analysis： The age, merging, hypertension, diabetes, coronary heart disease, smoking history, history of stroke, multiple cerebral infarction, infarct area（frontal lobe, temporal lobe and basal ganglia） of the two groups had the statistically significant differences（P〈0.05）; Multiariable Logistic regression analysis： The age, hypertension, diabetes, hyperlipidemia, multiple cerebral infarction, infarct area（frontal lobe and basal ganglia） are the independent risk factors of the VD after the IS. Conclusion Age, hypertension, diabetes, hyperlipidemia, multiple cerebral infarction, infarct area（such as the frontal lobe and basal ganglia） are the independent risk factors of the VD after the IS, should be strengthened the early prevention and treatment for the VD of such IS patients.