高渗盐水雾化治疗小儿类百日咳综合征的疗效观察

Effects of the inhaled hypertonic saline on children with pertussis-like syndrome

目的探讨高渗盐水雾化治疗小儿类百日咳综合征的临床疗效。方法我院2012年2月～2015年10月收治的小儿类百日咳综合征患儿96例,随机分为治疗组（48例）和对照组（48例）,两组均给予相同的常规综合治疗。治疗组给予高渗盐水（10%氯化钠溶液1 ml＋灭菌注射用水2 ml）雾化,2次/d,对照组给予生理盐水3 ml雾化,2次/d。比较两组患儿的痉咳缓解时间、肺部阳性体征消失时间、住院时间、住院费用及临床总有效率。结果治疗组患儿痉咳缓解时间、肺部阳性体征消失时间、住院时间、住院费用分别为（6.35±1.31）d、（4.31±1.17）d、（6.85±1.47）d、（3127.23±330.49）元,对照组为（7.27±1.30）d、（5.10±1.52）d、（8.27±1.32）d、（3479.50±273.09）元,治疗组患儿痉咳缓解时间、肺部阳性体征消失时间、住院时间均短于对照组,住院费用低于对照组,差异有统计学意义（P〈0.05）;治疗组患儿的治疗总有效率为95.8%高于对照组的81.3%,差异有统计学意义（P〈0.05）,且未发现不良反应。结论高渗盐水雾化治疗小儿类百日咳综合征有确切疗效,且方便、安全、经济。

Objective To investigate the clinical effect of the inhaled hypertonic saline on children with pertussis-like syndrome.Methods 96 patients diagnosed as having pertussis-like syndrome and treated in our hospital from February2012 to October 2015 were collected into this study,who were randomly divided into observation group（treated with hypertonie saline inhalation,n=48） and control group（treated with normal saline inhalation,n=48）,the basic treatment of two groups were same.The time of the clinical symptoms and pulmonary physical signs,the hospitalization time,the hospitalization cost and the total effective rate were compared.Results In the observation group,the time of the clinical symptoms,the time of the pulmonary physical signs,the hospitalization time,the hospitalization cost and the total effective rate was（6.35±1.31） days,（4.31±1.17） days,（6.85±1.47） days,（3127.23±330.49） yuan and 95.8%respectively,while in the control group was（7.27±1.30） days,（5.10±1.52） days,（8.27±1.32） days,（3479.50±273.09） yuan and 81.3%,the differences between two groups were significant（P〈0.05）.Conclusion Using the inhalated hypertonic saline to treat children pertussis-like syndrome is effective,safety and economical.