超声测量胎儿鼻前软组织厚度和鼻骨长度对唐氏综合征筛查的价值

Value of ultrasonic measurement of fetal anterior nasal soft tissue thickness and nasal bone length in Down′s syndrome screening

目的探讨分析超声测量胎儿鼻前软组织厚度和鼻骨长度筛查唐氏综合征（DS）的价值。方法选取2010年10月～2015年10月我院收治的中孕期41例存活的DS胎儿作为试验组,同期选取41例存活的正常胎儿作为对照组,采用超声测量两组胎儿的鼻前软组织厚度和鼻骨长度并进行对比分析。结果试验组胎儿鼻前软组织厚度明显厚于对照组,差异有统计学意义（P〈0.01）;对照组胎儿鼻骨长度均正常发育,而试验组胎儿鼻骨长度明显短于对照组,差异有统计学意义（P〈0.01）。结论与正常胎儿相比,DS胎儿鼻前软组织厚度增厚更明显,联合鼻骨长度发育情况进行超声测量,对胎儿DS的筛查有着十分重要的作用。

Objective To discuss and analysis the value of ultrasonic measurement of fetal anterior nasal soft tissue thickness and nasal bone length in Down′ s syndrome screening.Methods 41 survived fetuses with Down′ s syndrome treated in our hospital from October 2010 to October 2015 were selected as experiment group,and another 41 healthy fetuses were selected as control group.The anterior nasal soft tissue thickness and nasal bone length were measured by ultrasound and the results were analyzed.Results The anterior nasal soft tissue thickness in the experiment group was significantly thicker than that in the control group（P〈0.01）.The nasal bone length in the experiment group was significantly longer than that in the control group,whose nasal bones all developed normally（P〈0.01）.Conclusion Compared with normal fetuses,the increase of anterior nasal soft tissue thickness is significantly thicker in fetuses with Down′ s syndrome,which is of great value in Down′s syndrome screening when combined with ultrasonic measurement of nasal bone length.