男性在抗阻训练过程中摄取葫芦巴糖苷补剂的益处:一项随机对照预实验研究(英文)

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

目的:运用预测、随机、双盲、安慰剂对照实验设计,测试服用葫芦巴种子糖苷补剂对进行8周抗阻训练健康男性的肌肉代谢、雄激素指标、体脂含量等相关生理参数的作用及安全性。方法:将60名健康男性随机分为2组,按照1:1比例剂量分别服用葫芦巴种子胶囊(每粒300 mg,每日2次)和安慰剂。所有受试者参加一项受监督抗阻训练,训练为期8周,每周4次,在训练前后记录相关数据。监测结果包括血清睾酮水平、肌肉力量、正确完成次数、合成代谢活性的生化指标(血清肌酐、血尿素氮)及体脂百分比。标准安全性测验方法包括不良事件监测、生命特征,以及血液、生化和尿检验。结果:与安慰剂对照组相比,葫芦巴种子补剂对受试者新陈代谢和雄激素活性均有显著作用。葫芦巴种子补剂能明显改善体脂含量,但不会降低肌肉力量和正确完成次数,其安全性和耐受性均良好。结论:葫芦巴种子补剂能对从事抗阻训练的男性产生有益作用,且无任何临床副作用。

Purpose： To evaluate the efficacy and safety of the glycoside fraction of fenugreek （Trigonellafoenum-graecum） seeds （Fenu-FG） on physiologi- cal parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design. Methods： Sixty healthy male subjects were randomized to ingest capsules of Fenu-FG （1 capsule of 300 rag, twice per day） or the matching placebo at a 1：1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment （baseline） and at the end of the treatment （8 weeks）. The efficacy outcome included serum testosterone （total and free） levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity （serum creatinine and blood urea nitrogen）, and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed. Results： Fenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplemen- tation was found to be safe and well-tolerated. Conclusion： Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects.