豫北地区小儿轮状病毒腹泻流行病学研究

Study on Infantile Rotavirus Diarrhea in Northern Henan

目的了解近9年豫北地区小儿轮状病毒腹泻流行病学特征。方法选取2007年1月—2015年12月间鹤壁市人民医院收治的学龄前非菌性腹泻患儿,采集患儿粪便标本,酶联免疫吸附法检测标本中的轮状病毒,对检测结果呈阳性标本采用RT-PCR、电泳技术分析病毒株G血清型、P血清型。结果研究患儿中轮状病毒阳性率52.20%,2007—2012年轮状病毒检出率呈逐年下降的趋势,2013年有所上升,2014年起明显降低;每年9月到次年3月的冬季和初春为小儿腹泻轮状病毒高发季节,男性轮状病毒感染率高出女性约2倍;轮状病毒G3型、P8型为主要流行株,G9型呈逐年上升趋势。轮状病毒感染集中在0-24月龄的婴幼儿,其中以7-12月龄感染率最高。小儿轮状病毒腹泻主要临床表现为腹泻和呕吐。结论轮状病毒是豫北地区小儿腹泻的主要致病原,其中G3型和P8型为主要流行株,应加强每年9月到来年3月间高发年龄段婴儿轮状病毒性腹泻的防治工作。

Objective To investigate the recent 9 years in northern regions of the epidemiological characteristics of infantile rotavirus diarrhea.Methods From 2007 January to December 2015 in Hebi City People＇s hospital were preschool non bacterial diarrhea children and collected stool samples,ELISA method to detect rotavirus adsorption,the detection results were positive samples by RT-PCR and electrophoresis analysis of virus strains of serotype G and P serotypes.Results Rotavirus positive rate was 52.2%,from 2007 to 2012 annual ring type virus detection rate,increase in 2013,2014 decreased;September to next March in winter and early spring for infantile diarrhea rotavirus incidence season,male rotavirus infection rate is about 2 times higher than women;rotavirus G3 type,P8 were the main epidemic strains and G9 was a rising trend.Rotavirus infection in infants aged 0~24 months of age,which is the highest rate of 7~12 months of age infection.Diarrhea and vomiting were the main clinical manifestations of infantile rotavirus diarrhea.Conclusion Rotavirus is the leading cause of diarrhea in children,the G3 and P8 type was the predominant strain should be strengthened in September to next year March.high risk age of Infant Rotavirus Diarrhea prevention and control work.