论中药丸剂“类玻璃化转变”的干燥机制与品质调控对策

arying mechanism of “like-glass transition” and quality control strategy on Chinese materia medica pills

丸剂干燥品质研究(如假干燥、表面结壳、裂纹等)是中药药剂学研究的难点。目前中药丸剂在干燥和储存过程中的品质变化机制、干燥及储存条件与品质的关系仍停留在实验研究阶段,尚无较合适的理论能加以解释和研究。尝试运用玻璃化转变理论来探讨中药丸剂在干燥和储存过程中干燥特性和物理状态变化的过程、品质变化的机制以及控制品质变化的策略方法。

Study on drying quality of pill（false drying, surface crust, and cracks） is the difficulty in pharmaceutic research of Chinese materia medica（CMM）.The influence mechanism and relationship of quality of CMM pill during drying and storage are still in the experimental stage, and there is no more appropriate theory to explain and research. This paper attempts to use glass transition theory to explore drying characteristics and physical state change process and mechanism of quality change and to control the quality change of strategy of CMM pill during drying and storage.