乳腺神经内分泌癌的诊断及治疗

Diagnosis and management of neuroendocrine breast cancer

乳腺神经内分泌癌是一组形态特征与发生在胃肠道和肺部的神经内分泌肿瘤相同的肿瘤,肿瘤中有50%以上的癌细胞表达神经内分泌标记。其中以实性神经内分泌癌较多,大细胞神经内分泌癌罕见。其临床特征与其他类型的乳腺癌相比没有明显差别。通过乳腺X线摄影、B超检查或MRI扫描来确诊乳腺神经内分泌癌非常困难。目前对乳腺神经内分泌癌的个体化治疗策略没有统一的认识,大多采用以手术为主的综合治疗。

Neuroendocrine breast cancer （NEBC） is a group of tumor that share the same morphological characteristics of the gastrointestinal tract and pulmonary neuroendocrine tumor. In the tumor more than 50% of the cancer cells express immunohistochemistry neuroendocrine markers. Solid neuroendocrine carcinoma is more relatively, and large cell neuroendocrine carcinoma is rare. Its clinical characteristics had no significant difference compared with other types of breast cancer. Through mammography, ultrasound, or MRI scans to identify breast neuroendocrine carcinoma is very difficult.Currently there is no unified individualized treatment strategies on neuroendoerine carcinoma of the breast, the mostly using treatment is operation and adjuvant therapy.