胃癌组织中HER-2和Survivin蛋白的表达及临床意义

Expression and Clinical Significance of HER-2 and Survivin in Gastric Cancer Tissue

目的探讨胃癌组织中HER-2和Survivin蛋白的表达情况以及二者与临床病理特征的关系。方法采用免疫组化方法及图像分析技术分别对70例胃癌组织中HER-2和Survivin蛋白的表达情况进行检测,并分析二者与胃癌患者临床病理学参数的关系。结果胃癌组织中HER-2和Survivin蛋白的表达与分化程度、TNM分期及淋巴结转移有关(均P<0.05),与性别、年龄及肿瘤大小无关。阳性率相关性分析及蛋白半定量相关性分析均显示HER-2蛋白与Survivin蛋白表达呈正相关(均P<0.01)。结论 HER-2和Survivin蛋白的表达均与分化程度、TNM分期及淋巴结转移有关,且胃癌组织中HER-2蛋白和Survivin蛋白之间具有正向调节关系。

Objective To investigate the expression of human epidermal growth factor receptor-2（HER-2）and Survivin protein in gastric cancer tissue,and explore its relationship with clinicopathological characteristics. Methods Immunohistochemistry assay was used for detection of HER-2 and Survivin protein expression in 70 gastric cancer biopsy samples. The relationship with the clinicoathological parameters in patients with gastric cancer was analyzed. Results The expression of HER-2 and Survivin protein was correlated with tumor differentiation,TNM stage and lymph node metastasis（all P〈0.05）,but not with sex,age,the diameter of tumor. The correlation analysis of positive rate and the semi-quantitative protein expression showed that the expression of Survivin and HER-2 was significantly positively related（all P〈0.01）. Conclusion The positive expression of HER-2 and Survivin protein in gastric cancer correlates with tumor differentiation,TNM stage and lymph node metastasis. HER-2 expression significantly correlates with Survivin at the protein level in gastric cancer tissues.