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单纯超重与肥胖不育患者体外受精-胚胎移植助孕临床结局 被引量:16

Effect of simple overweight or obesity on IVF-ET outcome
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摘要 目的探讨体重指数(BMI)对非多囊卵巢综合征(PCOS)不孕妇女体外受精-胚胎移植(IVF-ET)周期的临床结局影响。方法回顾性分析2011年6月至2015年9月在本中心进行IVF-ET治疗的不孕症患者的临床资料,共1 344个周期,年龄≤38岁,均采用短效长方案。根据BMI分为两组,正常体重组:18kg/m^2<BMI<24kg/m^2,1 021个新鲜周期;超重肥胖组:BMI≥24kg/m^2,323个新鲜周期。比较两组患者的一般临床资料和妊娠结局以评估BMI对IVF-ET治疗结局的影响。结果两组患者的基础内分泌、促性腺激素(Gn)刺激天数、获卵数、正常受精率、优质胚胎率、临床妊娠率及自然流产率均无显著性差异(P>0.05)。超重肥胖组的平均年龄[(30.44±3.70)vs.(29.60±3.56)Y]、不孕年限[(4.26±2.87)vs.(3.82±2.68)Y]及Gn刺激总量[(2 223±882)vs.(1 900±850)U]均高于正常体重组,且差异均有统计学意义(P<0.05);而全胚冷冻率低于正常体重组[49.84%(161/323)vs.58.86%(601/1 021)],差异有统计学意义(P<0.05)。结论排卵正常的肥胖患者IVF促排卵时Gn用量明显增加,临床妊娠率并不受影响。 Objective: To explore the impact of body mass index (BMI) on the outcome of IVF treatment without polycystic ovary syndrome, Methods: This retrospective study included 1 344 cycles from women≤38 years old undergone a conventional long protocol in our reproductive center from Jun 2011 to Sep 2015. The cycles were divided into two groups according to the BMI of the women:normal weight group(18 kg/m^2〈BMI〈24 kg/m^2,n= 1 021 cycles),overweight or obesity group(BMI〈24 kg/m^2 ,n=323 cycles). Results: The basic hormone levels, gonadotropin (Gn), Gn stimulation days, number of oocytes retrieved, normal fertilization rate, high quality embryo rate, clinical pregnancy rate and abortion rate were not significantly different (P〉0.05). Compared with the normal weight group,the age was significantly older [(30.44±3.70) vs. (29.60± 3.56) years]; the duration of infertility was significantly longer [(4.26±2.87) vs. (3.82±2.68) years]; the total gonadotropin doses used were significantly higher [(2 223±882)vs. (1 900±850) U] in the overweight or obesity group(all P〈0.05). However,the whole embryo freezing rate in the overweight or obesity group was significantly lower than that in the normal weight group[49.84%0 (161/323) vs. 58.86% (601/1 021)1 (P〈0.05). Conclusions: The over weight or obese women may require significantly high doses of gonadotropin to induce ovulation,but do not affect the pregnancy outcomes.
出处 《生殖医学杂志》 CAS 2016年第7期623-626,共4页 Journal of Reproductive Medicine
关键词 体重指数 肥胖 体外受精-胚胎移植 Body mass index Obesity IVF-ET
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参考文献15

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