心脏α_1肾上腺素能受体与心肌细胞凋亡

Cardiac alpha_1-adrenergic receptors and myocardial apoptosis

α_1肾上腺素能受体(α_1-ARs)在心脏中占据的比例虽少,但对心脏正常功能的维持有至关重要的作用,可通过下游信号通路的多向性激活抑制心衰时的病理性心肌重构:促使心肌细胞适应性肥大、抑制心肌细胞凋亡、增加心肌收缩性、诱导缺血预适应.心脏α_1-ARs主要位于细胞核内,依赖"由内向外"的信号通路来发挥心肌保护作用.本综述为α_1-ARs在抑制心肌细胞凋亡中的研究进展.

Cardiac alpha1-adrenergic receptors （α1-ARs） mediate important protective functions in the heart, although α1-ARs are only a small fraction of the total cardiac ARs. Cardiac α1-ARs activate pleiotropic downstream signaling to prevent pathologic remodeling in heart failure, and the mechanisms include activation of adaptive hypertrophy, prevention of myocardial apoptosis, augmentation of contractility, and induction of ischemic preconditioning. In the recent years, more and more studies showed that α1-ARs localize to the nucleus of cardiomyocytes and activate the “inside-out” signaling to cause cardioprotection. We summarize the recent progress of α1-ARs in preventing myocardial apoptosis.