4-苯基-3-氨基哌啶二盐酸盐的合成

Synthetic of 4-Phenylpiperidin-3-amine Dihydrochloride

以肉桂酸为原料,先后经酯化、Michael加成反应、环合、乙硼烷还原、钯碳催化氢化共5步反应制得目标化合物,其结构经1HNMR和MS确证。该工艺使用原料简单易得、合成路线短、反应条件温和,制备方法简便,总收率54.1%。

Starting from cinnamic acid,target product was obtained via esterification,Michael addition reaction,cyclization,reduction and catalytic hydrogenation. The structure was confirmed by1 HNMR and MS. The synthetic procedure was characterized by simple starting material,short reaction steps,mild conditions,and the total yield was high up to 54. 1%.