摘要
以肉桂酸为原料,先后经酯化、Michael加成反应、环合、乙硼烷还原、钯碳催化氢化共5步反应制得目标化合物,其结构经1HNMR和MS确证。该工艺使用原料简单易得、合成路线短、反应条件温和,制备方法简便,总收率54.1%。
Starting from cinnamic acid,target product was obtained via esterification,Michael addition reaction,cyclization,reduction and catalytic hydrogenation. The structure was confirmed by1 HNMR and MS. The synthetic procedure was characterized by simple starting material,short reaction steps,mild conditions,and the total yield was high up to 54. 1%.
出处
《化学试剂》
CAS
北大核心
2016年第7期695-697,共3页
Chemical Reagents
基金
贵州省普通高等学校药物化学工程研究中心资助项目(黔教合KY字[2014]219号)
贵州省科学技术基金资助项目(黔科合J字[2012]2031号)
贵州省中药现代化资助项目(黔科合ZY字[2013]3019号)