创伤性脑损伤后免疫反应的研究进展

Research Progress in Immune Response Following Traumatic Brain Injury

创伤性脑损伤是导致青壮年神经功能残疾的主要原因之一。急性脑损伤后,因血脑屏障破坏,中枢神经系统的免疫豁免地位随之改变,最终导致特殊的固有免疫和适应性免疫反应。淋巴细胞在调节中枢神经系统损伤的免疫修复过程中起到关键性作用。更好地理解免疫细胞的生物学特性及其与自身免疫的关系,协调固有性免疫和适应性免疫系统之间的作用,加强对脑损伤后免疫系统的保护,平稳安全地恢复免疫系统稳态,将有助于脑损伤的预后。

Traumatic brain injury （TBI） is the leading cause of neurological disability in the world, especially among young adults. After acute brain injury, due to blood-brain barrier breakdown,the immune privileged status is completely changed and the central nervous system（CNS） is then able to coordinate an innate immune response, which finally leads to the mobilization of the specific innate and adaptive immune response. Lymphocytes play key roles in regulating CNS injury and repair. To better understand the biological characteristics of immune cells and its relationship with autoimmunity, coordinate the influence on the innate and adaptive immune system, strengthen the neuroprotection of the immune system after TBI and safely restore immune homeostasis, will contribute to the prognosis of brain injury.