摘要
胸腺基质淋巴细胞生成素(TSLP)是一类白细胞介素7(IL-7)样细胞因子,在变态反应中具有重要作用。近些年,学者们逐渐将目光聚焦在TSLP与风湿性疾病的关联。在类风湿关节炎、系统性硬化症中TSLP表达显著增高,与疾病进程显著相关;而在原发性干燥综合征中TSLP表达降低,与相关临床指标呈负相关。TSLP在多种风湿性疾病的病理机制中扮演着不同角色,有望成为崭新的干预靶点。
Thymic stromal lymphopoietin （TSLP） is an interleukin-7 （IL-7）-related cytokine that has been studied abundantly in allergic reaction. Recently there are more researches on TSLP in various rheumatic disorders. TSLP is significantly overexpressed in rheumatoid arthritis （RA） and systemic scleroderma （SSc） which is correlated with disease progress; whereas TSLP is underexpressed in primary Sjogren syndrome （pSS）, and showed negative correlation with the related clinical index. TSLP plays different roles in multiple rheumatoid diseases and is become to become the potential therapeutic target.
出处
《医学综述》
2016年第13期2508-2511,共4页
Medical Recapitulate
