儿童幽门螺杆菌感染规范化治疗

Standardized treatment for Helicobacter pylori infection in children

幽门螺杆菌(Hp)治疗可减少儿童Hp相关性胃炎、消化性溃疡的复发。儿童中常用的Hp一线治疗方案是以质子泵抑制剂(PPI)联合2种抗生素的三联疗法。但由于耐药菌株、患者依从性等问题的存在,Hp根除率逐年下降。根除儿童Hp需个性化治疗。

It is well known that a successful eradication of H,pylori dramatically reduces the rate of recurrence of gastritis and peptic ulcers in affected children. The recommended first- line eradication therapy for H.pylori infection has been triple therapy consisting of a proton pump inhibitor and two antibiot- ics. However, the eradication rate has declined in recent years, due to an increased bacterial resistance to antibiotics or de- creased compliance with the patients. The treatment of H.pylo- ri infection in children should be personalized.