幽门螺杆菌感染与儿童胃肠道外疾病研究进展

Research progress of Helicobacter pylori infection in children with extradigestive diseases

幽门螺杆菌(Hp)感染是人类最常见的感染之一。Hp不仅可直接作用于其定植宿主胃,引起胃肠道疾病,还能通过产生一系列激素、免疫分子、细胞因子和趋化因子等对胃肠道以外的系统产生危害。阐述Hp感染与儿童胃肠道外疾病如缺铁性贫血、慢性特发性血小板减少性紫癜、生长迟缓、哮喘、过敏性疾病、糖尿病、皮肤自身免疫性疾病、口咽部疾病、渗出性中耳炎,以及血管内皮功能紊乱等关系,有助于提高人们对Hp感染的认识,进一步拓宽抗Hp治疗的适应证。

Helicobacter pylori （Hp） infection is one of the most common infections in human. Hp can not only directly colonize to the stomach of the host, causing gastrointestinal tract diseases, but also induce extradigestive disorders by gen- erating a series of hormone and immune molecules, cytokines and chemokines. In the article, the relationship between Hp in- feetion and extradigestive diseases in children is reviewed in order to improve people＇ s attention on the relationship, and provide more theoretical basis for the indication of anti-Hp treatment.