DE4D基因多态性与急性缺血性卒中及阿司匹林抵抗的相关性

Correlation of DE4D Polymorphisms Associated with Acute Ischemic Stroke and Aspirin Resistance

本研究选取2015年1月至2016年1月来我院就诊的183例急性缺血性脑卒中患者(脑卒中组)与同期就诊非脑卒中患者183例(对照组),分别进行DE4D基因多态性检测。对比两组中的SNP83发现脑卒中组基因型CC与CT分别高达77.05%、20.77%,而且C等位基因为87.43,均明显高于对照组;对比SNP87发现,在各基因型与等位基因的比较中,脑卒中组与对照组无明显差异。脑卒中组,SNP83与SNP87的CT、CC、TT基因型占比在对阿司匹林敏感患者中与对阿司匹林抵抗的患者中无明显差异。DE4D基因SNP83与急性缺血性卒中有密切联系,其中C等位基因越高,发病风险越高,相对应SNP87则与该疾病发生相关性较小,这可为早期诊断及预防缺血性脑卒中提供强有力的理论依据。

Patients with acute ischemic stroke（stroke group） with the same period of non-treatment of stroke patients（control group） in our hospital were selected,183 respectively,to test the polymorphism of DE4D,from January 2015 to January 2016.We analyzed the SNP83 of DE4D in each group and found that the propotion of genotype CC and CT in stroke group were as high as 77.05%,20.77%,the C allele 87.43%,significantly higher than that of the control.However,the SNP83 and SNP87 of DE4D didn＇t show a significant difference.In the stroke group,the propotion of CT,CC,TT were of no difference between aspirin-sensitive patients and aspirin-resistant patients.SNP83 in DE4D gene was closely linked to acute ischemic stroke,where the C allele is the higher,the risk is the greater.However,SNP87 was of less correlation to the disease.The research may provide a strong theoretical basis for early diagnosis and prevention of ischemic stroke.