奥美拉唑镁肠溶片和注射用奥美拉唑钠在急性颅脑损伤并发应激性溃疡出血患者中的疗效分析

Effect Analysis on Ogilvy & Mather Pull Down Magnesium Enteric-coated Metformin Hydrochloride and Omeprazole Sodium for Injection in Acute Craniocerebral Injury in Patients with Stress Ulcer Bleeding

目的:观察探讨奥美拉唑镁肠溶片和注射用奥美拉唑钠在急性颅脑损伤并发应激性溃疡出血患者中的疗效。方法:选取本院2013年1月-2014年12月收治的86例急性颅脑损伤并发应激性溃疡出血患者,按随机分配原则分为观察组和对照组,每组43例,观察组患者在对照组治疗基础上加用注射用奥美拉唑钠,对脑出血给予相应积极预防干预性措施,对照组患者仅采用奥美拉唑镁肠溶片及常规措施。记录治疗过程中并发症发生率如胃肠道功能衰竭等,在一个疗程后对其疗效进行评价,比较患者胃肠道功能衰竭发生率、焦虑情绪评分及临床效果。结果:观察组胃肠功能衰竭发生率为25.6%,对照组为62.8%,两组比较差异有统计学意义(P<0.05)。两组治疗前焦虑情绪评分比较,差异无统计学意义(P>0.05)。两组治疗后焦虑情绪评分比较,差异有统计学意义(P<0.05)。观察组总有效率为95.3%,对照组为74.4%,两组比较差异有统计学意义(P<0.05)。结论:奥美拉唑镁肠溶片和注射用奥美拉唑钠对急性颅脑损伤并发应激性溃疡出血患者疗效显著,且能明显改善胃肠道功能衰竭发生的风险率,改善急性颅脑损伤并发应激性溃疡出血患者发病导致的神经缺损,减少脑水肿等临床表征,降低血肿周围低密度区面积,缓解临床症状。缓解患者焦虑情绪,有利于保持心理健康。采用奥美拉唑镁肠溶片和注射用奥美拉唑钠联合治疗具有可行性及安全性,值得临床上进一步推广应用。

Objective： To study the effect of Ogilvy ＆ Mather Pull Down Magnesium Enteric-coated Metformin Hydrochloride and Omeprazole Sodium for Injection in acute craniocerebral injury complicated with stress ulcer bleeding.Method： In our hospital from January 2013 to December 2014 86 patients with acute craniocerebral injury complicated with stress ulcer bleeding patients were selected, and they were divided into the observation group and the control group according to the principle of random assignment, 43 cases in each group.On the basis of the control group treatment, patients in the observation group were given Omeprazole Sodium for Injection, cerebral hemorrhage was given positive prevention and intervention measures.Patients in the control group were only given Ogilvy ＆ Mather Pull Down Magnesium Enteric-coated Metformin Hydrochloride and conventional measures.The complications occurred in the course of treatment, such as gastrointestinal function failure, and so on, after a course of treatment to evaluate the efficacy of the treatment, gastrointestinal function failure rate, anxiety score and clinical effect of two groups were compared.Result： The incidence rate of gastrointestinal failure in the observation group was 25.6%, the control group was 62.8%, there was statistical significance （P〈O.05） .There were significant differences in anxiety scores between two groups （P〈0.05） .In the observation group, the total effective rate was 95.3%, the control group was 74.4%, there was significant difference （P〈0.05） .Conclusion： Ogilvy ＆ Mather Pull Down Magnesium Enteric-coated Metformin Hydrochloride on acute craniocerebral injury complicated with stress ulcer bleeding patients has an obvious curative effect and improve the risk of patients with gastrointestinal function failure rate and the acute craniocerebral injury patients complicated with stress ulcer hemorrhage patients caused by nerve defect, reduce brain edema and clinical characterization and the perihematoma hypodensity area, relieve the clinical symptoms. To ease the anxiety of patients, it is beneficial to maintain the mental health of patients.Using Ogilvy ＆ Mather Pull Down Magnesium Enteric-coated Metformin Hydrochloride combination therapy is feasible and safe, which is worthy of further application.