康莱特联合GP方案治疗晚期非小细胞肺癌的Meta分析

Kanglaite combined with GP and nonsmall-cell lung cancer: a meta-analysis

目的系统分析康莱特联合GP方案（吉西他滨＋顺铂）治疗晚期非小细胞肺癌的有效性。方法计算机检索Pub Med、EMbase数据库、中国科技期刊全文数据库、万方数据库,纳入符合入选标准的文献进行统计分析。结果共纳入4篇文献,结果显示康莱特＋GP组与单纯GP化疗组治疗有效率无明显差异（RR=1.21,95%CI 0.9～1.62）;康莱特＋GP组生活质量明显提高（RR=1.58,95%CI 1.28～1.96）。结论康莱特联合GP方案化疗不影响晚期非小细胞肺癌患者治疗有效率,但可明显改善其生活质量。

Objective A meta-analysis of published studies was conducted in the present study,aims to estimate the validity of Kanglaite combined GP scheme in treatment non-small cell lung cancer（ NSCLC）. Methods CJFD and Wan Fang database was searched up to January,2015 to identify eligible studies. Pooled relative risk（ RR） estimates and 95% confidence intervals（ CIs） were calculated. Results Effective rate of Kanglaite ＋ GP was equal to GP in treating NSCLC.（ RR = 1. 21,95% CI 0. 9-1. 62）. Life quality improved significantly in Kanglaite ＋ GP group（ RR = 1. 58,95% CI 1. 28-1. 96）. Low publication bias was observed. Conclusion Kanglaite significantly improved life quality of NSCLC patients,and more research is needed to confirm this finding.