影像技术在动物实验中的应用

The Application of Image Technology in Animal Experiment

影像技术研究是借助于某种介质与机体的相互作用,把内部组织器官结构、密度以影像方式表现出来。常用的方法包括:X线、CT、MRI、超声、血管造影和生物发光等。人们通过各种影像技术可以连续、准确、甚至无创观察动物体内疾病变化,极大提升了实验研究水平,推动疾病检测由传统的解剖形态,向功能、代谢,甚至是受体和基因的分子水平发展,其中涉及的福利是指在整个影像检测过程中保证动物的康乐。目的就是在动物福利与"人类利益"之间找到平衡点。即关注影像检测中可能影响动物康乐的因素,从而减少动物的痛苦;同时,当福利条件满足动物康乐时,可最大限度地发挥影像实验的效能。

The image technology is to show the internal structure and density of the internal organs in the form of image via the interaction between the media and the body. Commonly imaging methods include X-ray,CT,MRI,ultrasound,angiography and biological luminescence etc. It can be continuous,accurate,and non-invasive to observe the changes of diseases in animals by different image technology. By these methods the level of experimental research was enhanced greatly,and the pattern of disease detection was promoted from traditional anatomical morphology to molecular level development of functional,metabolic,and even receptor and gene.Which involves the welfare refers to ensure the animal＇s well being during the whole image detection process. The purpose is to find a balance between animal welfare and human interests. That is concerned about the factors that may affect the animal＇s well being,and less of an animal＇s pain in the process of image. At the same time,when the welfare conditions are satisfied with animal well being the effectiveness of image experiments can be maximized.