血清同型半胱氨酸、尿酸水平与帕金森病的相关性分析

Correlation of serum Hcy,UA levels and Parkinson＇s disease

目的：探讨帕金森病患者血清同型半胱氨酸和尿酸的含量变化。方法选择2015年4月至2016年3月治疗的帕金森病患者46例为病例组，同时选择同期住院的其他疾病患者57例为对照组，检测两组患者的血清同型半胱氨酸和尿酸含量，并对其进行分析。结果病例组血清同型半胱氨酸、血清尿酸含量分别为（17．82±3．12）μmol／L、（321．42±79．42）μmol／L，对照组血清同型半胱氨酸、血清尿酸含量分别为（10．12±3．05）μmol／L、（420．15±70．18）μmol／L，帕金森病患者血清同型半胱氨酸含量高于对照组（t ＝12.608，P ＜0．01），而血清尿酸含量低于对照组（t ＝6．692，P ＜0．01）；中晚期帕金森病患者的同型半胱氨酸含量[（18．86±3．12）μmol／L]高于早期患者[（16．16±3．04）μmol／L]（t ＝2．378，P ＜0．05）；帕金森患者的血清 Hcy 的含量与帕金森综合评分量表（UPDRS）评分呈正相关关系（r ＝0．462，P ＝0．037）。结论血清同型半胱氨酸和尿酸含量变化与帕金森病的发生有关。

Objective To study the variation of serum Hcy and UA of Parkinson＇s disease.Methods 46 pa-tients with Parkinson＇s disease in our hospital from April 2015 to March 2016 were selected as observation group,and 57 patients with other disease at the same time were selected as control group.The contents of serum Hcy and UA of the two groups were analyzed and compared.Results The contents of serum Hcy and UA of the observation group were （17.82 ±3.12）μmol/L,（321.42 ±79.42）μmol/L.Those of the control group were （10.12 ±3.05）μmol/L, （420.15 ±70.18）μmol/L.The content of serum Hcy of observation group was higher than the control group,the con-tent of serum UA of the observation group was lower than the control group（t =12.608,P 〈0.01）.Hcy content of middle and late patients[（18.86 ±3.12）μmol/L]was higher than early patients[（16.16 ±3.04）μmol/L]（t =2.378,P 〈0.05）,serum Hcy level was positively correlated with UPDRS（r =0.462,P =0.037）,the differences were significant.Conclusion Changes of serum Hcy and UA levels were related to the occurrence of Parkinson＇s disease.