川崎病合并肺炎支原体感染患儿免疫指标变化及临床意义

Changes and clinical significance of immune indexes in children with Kawasaki disease and mycoplasma pneumonia infection

目的探讨川崎病(KD)合并肺炎支原体(MP)感染患儿免疫指标的变化和临床意义。方法将40例KD患儿分为MP感染组16例和非MP感染组24例。比较两组患儿白细胞计数(WBC)、中性粒细胞百分比(NE%)、血小板计数(PLT)、红细胞沉降率(ESR)、高敏C反应蛋白(hs-CRP)、降钙素原(PCT)、血清免疫球蛋白(Ig)、补体、外周血中T淋巴细胞亚群和冠状动脉病变(CAD)发生率的差异。结果 MP感染组hs-CRP、PCT、IgG、C_3、CD4^+/CD8^+、CD19^+水平及CAD发生率均显著高于非MP感染组(P<0.01),而CD8^+水平显著低于非MP感染组(P<0.01)。结论 KD合并MP感染患儿的体液免疫和细胞免疫功能紊乱更为严重,炎症反应更为强烈,并发CAD的概率更大,临床需加以重视。

Objective To explore the changes and clinical significance of immune indexes in children with Kawasaki disease（ KD）and mycoplasma pneumonia（ MP） infection. Methods A total of 40 children with KD were divided into MP group（ n = 16） and nonMP group（ n = 24）,respectively. The levels of white blood count（ WBC）,percent of neutrophils（ NE%）,platelet count（ PLT）,erythrocyte sedimentation rate（ ESR）,high sensitivity C-reactive protein（ hs-CRP）,procalcitonin（ PCT）,serum immunoglobulins,complement and T lymphocyte subsets,and incidence of coronary artery disease（ CAD） between two groups were compared. Results The levels of hs-CRP,PCT,Ig G,C_3,CD4~＋/ CD8~＋,CD19~＋and incidence of CAD in MP group were obviously higher than that in non-MP group（ P〈0. 01）,while the level of CD8＋was obviously lower than that in non-MP group（ P〈0. 01）. Conclusion Children with KD and MP infection have more serious humoral and cellular immunity function disorders,inflammatory response and higher incidence of CAD.This problem is worthy of particular mention.