超声造影剂量对肾恶性肿瘤时间-强度曲线参数影响

Effect on time-intensity curve parameters with different doses of ultrasound contrast agent in renal malignant tumors

目的探讨超声造影剂量对肾恶性肿瘤造影时间-强度曲线参数的影响。方法将31例肾恶性肿瘤患者按剂量1.2、1.5、2.0、2.4 ml分为4组进行超声造影检查,应用时间-强度曲线获得4组定量参数,包括始增时间、达峰时间、峰值强度、曲线上升支斜率、曲线上升支下面积,分析4组参数与造影剂剂量的关系。结果始增时间、达峰时间均随剂量增加而缩短,2.4 ml组与其他3组间差异有统计学意义(P<0.05);峰值强度随造影剂量增加而增强,2.4 ml组与1.2 ml组、1.5ml组差异均有统计学意义(P<0.05);曲线上升支斜率、曲线上升支下面积在4组间差异无统计学意义(P>0.05)。结论一定范围内造影剂量对时间-强度曲线参数影响不显著,但增至2.4 ml时差异较显著。

Objective To analyze the effect on time-intensity curve（ TIC） parameters with different doses of ultrasound contrast agent in renal malignant tumors. Methods Thirty-one cases of renal cancer patients were administrated with Sono Vue at four dosage groups（ 1. 2 ml,1. 5 ml,2. 0 ml,2. 4 ml） respectively. Contrast-enhanced ultrasound was performed before operation. Enhancement images were analyzed quantitatively by TIC and the parameters of four groups such as arrival time,time to peak,peak intensity,ascending slope rate,and area under ascending curve were acquired and analyzed. Results The arrival time and the time to peak were decreased along with the dosage in four groups and significant differences（ P〈0. 05） were observed between 2. 4 ml groups and other dosage groups. The peak intensity was increased along with the dosage in four groups and significant differences were found between 2. 4 ml group and 1. 2 ml group,1. 5 ml group（ P〈0. 05）. There were no significant differences in four groups on the ascending slope rate and the area under ascending curve（ P〈0. 05）. Conclusion There is no significant differences on TIC with a certain range of dosage on CEUS for evaluating renal tumors,but increased to 2. 4 ml dose may cause significant differences.