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Characterization of a recombinant Akabane mutant virus with knockout of a nonstructural protein NSs in a pregnant goat model 被引量:1

Characterization of a recombinant Akabane mutant virus with knockout of a nonstructural protein NSs in a pregnant goat model
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摘要 Dear Editor,Akabane virus(AKAV),an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the Europe.AKAV was first isolated from mosquitoes in Japan(Oya et al.,1961).Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical signs of disease,in utero infections result in abortion,premature birth,stillbirth。 Dear Editor,Akabane virus(AKAV),an orthobunyavirus,is transmitted primarily by biting midges and is widely distributed throughout the world except the Europe.AKAV was first isolated from mosquitoes in Japan(Oya et al.,1961).Although pregnant cows,ewes,and goats infected with AKAV exhibit no clinical signs of disease,in utero infections result in abortion,premature birth,stillbirth,
出处 《Virologica Sinica》 SCIE CAS CSCD 2016年第3期274-277,共4页 中国病毒学(英文版)
基金 supported in part by a Research and Development Project for Application in Promoting New Policies in Agriculture,Forestry and Fisheries grant from the Ministry of Agriculture, Forestry and Fisheries a Grant-in-Aid from the Ministry of Education,Culture,Sports,Science and Technology of Japan
关键词 病毒特性 非结构蛋白 基因敲除 怀孕 山羊 NSS 突变体 重组 pregnant mutant abortion premature birth primarily vaccine throughout removed inoculated
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