短期强化内科治疗对前循环脑梗死二级预防的疗效分析

Short-Term Intensive Medical Therapy Former Efficacy of Secondary Prevention of Cerebral Circulation

目的 探讨短期强化内科治疗对前循环脑梗死二级预防疗效。方法 选取自2012年1月-2015年6月在我院接受治疗的客家地区前循环脑梗死患者200例,根据治疗方式的不同分为强化内科组（观察组）和对照组,每组患者100例。观察组于治疗第1天给予阿司匹林100 mg＋硫酸氢氯吡格雷300 mg＋阿托伐他汀钙80 mg,第2～14天给予阿司匹林100 mg＋硫酸氢氯吡格雷75 mg＋阿托伐他汀钙40 mg进行治疗;对照组自治疗第1天起给予阿司匹林100 mg＋阿托伐他汀钙40 mg进行治疗,两组治疗周期均为14天。观察两组患者治疗14天后的血浆血脂水平、超敏C反应蛋白（HsCRP）、凝血酶原时间（PT）、纤维蛋白原（FIB）和血小板的计数（PLT）的表达;观察两组患者治疗前后的NIHSS评分和Barthel指数以及治疗14天后的相关并发症情况。结果 治疗14天后,观察组的血浆血脂水平总体低于对照组,HsCRP和FIB计数明显低于对照组,PT和PLT计数明显高于对照组;观察组的Barthel指数高于对照组,NIHSS评分低于对照组,均差异具有统计学意义（P〈0.05）;观察组的并发症情况与对照组无明显差异（P〉0.05）。结论 短期强化内科治疗对于前循环脑梗死二级预防更为安全有效,值得临床应用。

Objective To investigate the effect of secondary prevention of short - term intensive medical therapy before circulation infarctionl Methods 200 Patients chosen from January 2012 to June 2015 in our hospital of Hakka area circulation infarction divided into strengthen the internal medicine group （observation group） and the control group. According to different ways of treatment, 100 patients Example were observed in the treatment group treated with aspirin 100 mg＋ the first day of clopidogrel hydrogen sulfate 300 mg＋ atorvastatin calcium 80 mg, 2 - 14 day aspirin 100 mg ＋ clopidogrel bisul- fate 75 mg ＋ 40 mg atorvastatin calcium treatment; control group patients since the first day of treatment aspirin 100 mg＋ 40 mg atorvastatin calcium treatment, two treatment cycles are 14 days. 14 days of treatment were observed in plasma lipid levels, high sensitive C - reactive protein （ HsCRP）, thrombin, fibrinogen （FIB） and platelet count （PLT） expression of the original time （FF）, the patient observation and treatment groups before and after the NIHSS score and Barthel index, and 14 days of treatment - related complications. Results The plasma lipid levels of observation group patients after 14 days were o- verall than the control group patients, HsCRP and FIB counts were significantly lower in patients; PT and PLT counts were significantly higher in patients ; Barthel Index of observation group were higher than the control group patients ; NIHSS scores were lower, statistically significant differences were more （P 〈 0. 05 ）. The complications of two groups were not significantly different after 14 days treatment （P 〉 0.05 ）. Conclusion The short - term intensive medical therapy for secondary prevention of anterior circulation infarction safer and more effective, worthy of clinical application.