静息态功能磁共振在皮质下缺血性血管性认知损害中的应用

Application of resting-state functional magnetic resonance imaging in subcortical ischemic vascular cognitive impairment

皮质下缺血性血管病（subcortical ischemic vascular disease, SIVD）被认为是引起血管性认知损害（vascular cognitive impairment, VCI）的最重要和常见的原因。若能早期发现皮质下缺血性血管性认知损害（subcortical ischemic vascular cognitive impairment, SIVCI）或皮质下血管性认知损害（subcortical vascular cognitive impairment, sVCI）患者,会使血管性痴呆（vascular dementia, VaD）在发生之前得到识别甚至逆转其进程成为可能。最近的研究显示,静息态功能磁共振（resting-state fMRI, rsfMRI）有可能为 SIVCI 的诊断提供客观依据。文章对 rsfMRI 在 SIVCI 诊断中的应用进行了综述。

Subcortical ischemic vascular disease （SIVD） is considered to be the most important and common cause of vascular cognitive impairment （VCI）. If patients with subcortical ischemic vascular cognitive impairment （SIVCI） and subcortical vascular cognitive impairment （sVCI） can be found early, it is possible that vascular dementia （VaD） can be identified before occurrence and even reverse the process. Recent studies have shown that resting-state functional magnetic resonance imaging （rsfMRI） may provide the objective basis for the diagnosis of SIVCI. This article reviews the application of rsfMRI in the diagnosis of SIVCI.