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FTO基因与肥胖关系的研究进展 被引量：1

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摘要 肥胖是21世纪成人和儿童青少年严重的公共健康问题,肥胖的发病机制包括环境因素和遗传因素,其中遗传因素是发生肥胖的主要危险因素。脂肪含量和肥胖相关基因（fat mass and obesity associated gene,FTO）是经过全基因组关联研究（genome-wide association study,GWAS）发现的首个与人类肥胖有关联的候选基因[1]。
作者 刘琦琦 王宁 袁甜 高磊 贾海莲 包艳
机构地区 内蒙古科技大学包头医学院 包头医学院第二附属医院检验科
出处 《中国校医》 2016年第6期474-475,共2页 Chinese Journal of School Doctor
基金 国家自然科学基金(81560150) 内蒙古自治区高等学校科学研究项目(NJZY14264) 包头医学院博士科研启动基金项目(BSJJ201611)
关键词 FTO蛋白 人 肥胖症
分类号 R179 [医药卫生—妇幼卫生保健]
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参考文献25

  • 1Frayling TM, Timpson NJ, Weedon MN, et al.A common variant in the FTO gene is associated with body mass index and predisposes to child- hood and aduh obesity[J]. Science, 2007,316(5826):889-894.
  • 2Xu Y, Ling J, Yang M, et al. Rs7206790 and rs11644943 in FTO gene are associated with risk of obesity in Chinese school-age population [J]. PLoS One, 2014,9(9): e108050.
  • 3Apalasanay YD, Ming MF, Rampal S, et al. Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays [J ]. Braz J Med Biol Res,2012,45(12):1119-1126.
  • 4Gerken T, Girard CA, Tung YC, et al. The obesity-associaled FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase [J]. Science, 2007, 318 (5855):1469-1472.
  • 5Church C, Moir L, McMurray F, et al. Overexpression of Fto leads to increased food intake and results in obesity[J ]. Nar Genet, 2010, 42 (12):1086-1092.
  • 6Peeters A, Beckers S, Verrijken A, et al. Variants in the FTO gene are associated with common obesity in the Belgian population [J]. Mol Genet Metab, 2008, 93(4):481-484.
  • 7Gonzilez-Sinchez JL, Zabena C, Martlnez-Larrad MT, et al. Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain[ J ]. Clin Endocrine I, 2009, 70(3):390-393.
  • 8Legry V, Cottel D, Ferrires J,et al.Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICAStudy[J]. Metabolism, 2009, 58:(7) 971-975.
  • 9Hertel JK, Johansson S, Sonestedt E,et al. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41 504 subjec- ts from the Scandinavian HUNT, MDC, and MPP studies[J]. Diab- etes,2011, 60(5): 1637-1644.
  • 10Albuquerque D, N6brega C, Manco L. Association of FTO polymorph-isms with obesity and obesity-related outcomes in Portuguese child- ren[J]. PLoS One, 2013,8(1):e 54370.

二级参考文献34

  • 1Bouchard C. Childhood obesity : are genetic differences involved? Am J Clin Nutr,2009,89(5) :1494-1501.
  • 2Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nat Rev Genet,2005,6 (3) :221-234.
  • 3Rankinen T, Zuberi A, Chagnon YC, et al. The human obesity gene map : the 2005 update. Obesity ( Silver Spring) , 2006,14 (4) : 529-644.
  • 4Kuniholm MH. Replicating genome-wide association studies. Science ,2007,318 ( 5849 ) :390-391.
  • 5Goodman E, Daniels SR, Morrison JA, et al. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel Ⅲ definitions of metabolic syndrome among adolescents. J Pediatr,2004,145 (4) :445-451.
  • 6Fredriksson R, Hagglund M, Olszewski PK, et al. The obesity gene, FTO, is of ancient origin, upregulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology, 2008,149 (5) :2062-2071.
  • 7Robbens S, Rouze P, Cock JM, et al. The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J Mol Evol,2008,66( 1 ) : 80-84.
  • 8Gerken T, Girard CA, Tung YC, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependcnt nucleic acid demethylase. Science ,2007,318 (5855) : 1469-1472.
  • 9Fernandez AM, Kim JK, Yakar S, et al. Functional inactivation of the IGF-Ⅰ and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev,2001,15 (15) : 1926-1934.
  • 10Stratigopoulos G, Padilla SL, LeDuc CA, et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol ,2008,294(4) :1185-1196.

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中国校医
2016年 第6期

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