维生素D缺乏在小儿毛细支气管炎发病中的作用

Effects of Vitamin D Deficiency in Children with Bronchiolitis

目的:观察维生素D(VitD)缺乏在小儿毛细支气管炎发病中的作用。方法:选择VitD缺乏的毛细支气管炎患儿50例,随机数字表法分为实验组与对照组,所有患儿均给予抗感染及对症治疗,同时实验组给予补充VitD治疗,疗程1个月。检测两组患儿治疗前血清25-(OH)D3及IgA水平,1个月后复查25-(OH)D3及IgA水平。记录两组各项指标(患儿喘憋消失时间、肺部体征消失时间、住院天数)。结果:实验组患儿喘憋消失时间、肺部体征消失时间、住院天数较非对照组明显缩短(t=2.03、2.49、3.23,P均<0.05)。治疗前两组血清25-(OH)D3及IgA差异无统计学意(P>0.05)。治疗后实验组25-(OH)D3及IgA水平明显高于对照组(t=8.28、9.57,P均<0.01);治疗后实验组25-(OH)D3及IgA水平较治疗前有显著提高(t=8.28、9.57,P均<0.01)。结论:毛细支气管炎患儿血清25-羟维生素D3及IgA水平低下,补充VitD有助于缓解临床症状,提示VitD可能通过调节机体免疫功能进而影响毛细支气管炎的治疗,其在临床中的应用具有推广应用价值。

Objective： To investigate the effects of vitamin 1D deficiency in the pathogenesis of bronchioli tis in children. Methods： 50 cases of children with VitD deficiency were selected, who were randomly divided into the experimental group and the control group, all children underwent anti infection and symptomatic treatment. The experimental group was given additional VitD for 1 months. The levels of serum 25 （OH）D3 and IgA before treatment were detected in two groups, and the levels of 25-（OH）D3 and IgA were detected again after 1 month. The disappearing time of paroxysmal wheeze, pulmonary signs and admission duration were recorded. Results. The disappearing time of paroxysmal wheeze, pulmonary signs and admission dura tion in the experimental group were significantly shorter than the control group （t=2.03, 2.49, 3.23, all P 〈0.05）. There was no significant difference in the levels of serum 25-（OH） D3 and IgA of children before treatment between the two groups （P〉0.05）. After treatment, the levels of 25-（OH）D3 and IgA in the ex perimental group were significantly higher than those in the control group （t=8.28, 9.57, all P〈0.01） ; af ter treatment, the levels of 25 （OH）D3 and IgA in the experimental group were significantly increased than that before treatment （t =8.28, 9.57, all P〈0.01）. Conclusion： Children with bronchiolitis have lower levels of serum 25-（OH） D3and IgA, supplementary VitD helps to relieve clinical symptoms, which indicates VitDmay regulate the immune function t.o effect, treatment of bronchiolitis, and has popularization value in clinical application.