小剂量阿司匹林对宫腔粘连术后子宫内膜的影响

Effect of Low-dose Aspirin on Endometrium after Intrauterine Adhesion

目的:观察小剂量阿司匹林对宫腔粘连术后子宫内膜的影响。方法:82例宫腔粘连患者经宫腔镜分离术后随机分为观察组和对照组,每组各41例。术后对照组患者给予补佳乐3mg,3次/d,并于月经第21d开始服用黄体酮胶囊,连服5d;观察组患者在对照组的基础上增加服用小剂量阿司匹林50mg,1次/d,两组患者共治疗3个周期。结果:观察组患者内膜厚度及A型子宫所占比例明显高于对照组,子宫动脉血流指数(RI)及子宫动脉搏动指数(PI)较对照组明显降低;观察组患者宫腔形态与月经恢复有效率均高于对照组患者(P<0.05)。结论:小剂量阿司匹林可以改善子宫内膜及子宫动脉,恢复宫腔形态,值得临床推广应用。

Objective：To observe the effect of low dose aspirin on endometrium in patients with intrau-terine adhesions.Methods：82 cases undergoing intrauterine adhesions were divided into observation group and control group with 41 cases in each group.After surgery,the control group were given progynova 3 mg, 3 times/d,and on the 2 1 st day of menstrual cycle taking progesterone capsules for 5 days;the observation group was given low-dose aspirin 50 mg/d on the basis of the control group once a day.Two groups were treated for three cycles.Results：The endometrial thickness and A type uterus in the observation group were significantly higher than those in the control group,and the index （RI）of uterine artery blood flow and the index （PI）uterine artery pulsation were significantly lower than those in the control group;the rate of uter-ine cavity morphology and menstruation recovery in the observation were higher than those in the control group （P〈0.05）.Conclusion：Low-dose aspirin can improve the endometrium,uterine artery,and restore the shape of uterine cavity,which is worthy of clinical popularization and application.