地塞米松鞘内注射联合尼莫地平治疗外伤性蛛网膜下腔出血临床观察

Clinical observation on the treatment of traumatic subarachnoid hemorrhage using Dexamethasone intrathecal injection combined with Nimodipine

目的:探讨地塞米松鞘内注射联合尼莫地平治疗外伤性蛛网膜下腔出血的治疗效果。方法:将100例外伤性蛛网膜下腔出血患者随机分为对照组、治疗组各50例。对照组应用脱水、营养神经、尼莫地平等治疗;治疗组在对照组治疗基础上,应用地塞米松鞘内注射联合尼莫地平、腰穿脑脊液置换治疗。观察两组治疗效果。结果:治疗组并发症发生率、脑血管痉挛发生率、患者住院时间明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:地塞米松鞘内注射联合尼莫地平、腰穿脑脊液置换治疗外伤性蛛网膜下腔出血效果较好,可减少脑血管痉挛、脑积水、再出血等并发症的发生,减少患者住院天数。

Objective： To investigate the treatment effect of Dexamethasone intrathecal injection combined with Nimodipine in the treatment of traumatic subarachnoid hemorrhage. Methods： 100 patients with traumatic subarachnoid hemorrhage were randomly divided into the treatment group and the control group,50 in each group. Both groups were given traditional routine medical treatments like dehydration,neuroprotective treatment and Nimodipine. Dexamethasone intrathecal injection combined with Nimodipine and cerebrospinal fluid replacement were given to the treatment group in addition.The treatment effect of two groups was observed. Results： The patients in the treatment group had lower rate of complications and lower incidence of cerebral vasospasm, as well as less hospitalization days compared with the patients in the control group,the differences of which was statistically significant（P 0.05）. Conclusion：Dexamethasone intrathecal injection combined with Nimodipine and cerebrospinal fluid replacement has a good curative effect on traumatic subarachnoid hemorrhage, and can significantly reduce the incidence of cerebral vasospasm, hydrocephalus and rebleeding complications as well as the hospitalization days.