摘要
目的：对艾粉β-环糊精包合物的质量标准进行研究。方法：通过薄层色谱法、显微成像法和气相色谱法对包合物进行鉴别以及定性、定量分析。结果：显微成像法验证了包合物的形成;薄层色谱法鉴别可以检测出包合物中左旋龙脑对应的斑点,斑点清晰,空白对照组无干扰;采用气相色谱法对包合物中的左旋龙脑进行含量测定,6份艾粉β-环糊精包合物中左旋龙脑的载药量为15.11%~17.52%,平均载药量为16.18%,加样平均回收率为98%（RSD=0.67%）。结论：该研究方法操作简便,准确性高,可作为该包合物的质量控制参考标准。
OBJECTIVE：To research quality standard on aifen of β-CD inclusion complex .METHODS：To identify and qualitative and quantitative analyze the inclusion complex by TLC , microscopic imaging and GC .RESULTS：Microscopic imaging can verify the formation of inclusion complex , and the analysis of TLC showed the sample and contrast had the same color spots with similar RF value .GC to measure the content of L-borneol , The L-borneol content of 6 inclusion complex were 15.11%-17.52%.The average content was 16.18%; and the average recovery rate was 98%（ RSD=0.67%） .CONCLUSIONS： The methods were simple , accurate , and can be used for quality control reference standard for the inclusion complex .
出处
《中国医院用药评价与分析》
2016年第6期728-731,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家自然科学基金项目(No.81374065)
贵州省黔科合重大专项字(No.2013-6011)
关键词
艾粉
包合物
质量标准
Aifen
Inclusion complex
Quality standard
