硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的疗效观察

Observation on Efficacy of Magnesium Sulfate Combined with Low-dose Aspirin in Treatment of Pregnancy-induced Hypertension

目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数均较治疗前有明显改善,且改善程度明显优于对照组,差异均有统计学意义（P〈0.05）;观察组患者不良反应发生率为16.00%（8/50）,明显低于对照组的44.00%（22/50）,差异有统计学意义（P〈0.05）。结论：硫硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病效果较好,可有效改善患者临床症状,且安全性较高,值得临床推广。

OBJECTIVE：To probe into the clinical efficacy of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension.METHODS：100 patients with pregnancy-induced hypertension admitted from Aug.2014 to Aug.2015 were selected to be divided into control group and observation group via the random number table , with 50 cases in each .The control group were treated with 25%intravenous infusion of magnesium sulfate in 1-1.5 g per hour, 20 g for a day;the observation group additionally received oral aspirin based on the control group , 50 mg for a day. After treatment of 3 d, the efficacy, related laboratory indicators and adverse drug reactions in two groups were observed . RESULTS：The total effective rate of observation group was 94.00%（47/50）, significantly higher than that in the control group 60.00%（30/50）, the difference was statistically significant （ P 〈0.05）.After treatment, the blood viscosity, hematocrit , urinary protein excretion , peak-to-valley ratio of umbilical artery blood flow velocity and vascular resistance indicators of umbilical artery in observation group had been significantly improved compared with before treatment , and the improvement degree was better than that of control group , with statistically significant difference （P〈0.05）.The incidence of adverse drug reactions was 16.00%（8/50）, significantly lower than that of control group 44.00%（22/50）, with statistically significant difference （ P〈0.05 ） .CONCLUSIONS： The effects of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension is remarkable , which can significantly improve the clinical symptoms in patients with high safety .It is worthy of clinical application and promotion .