碳酸锂与氯氮平联合治疗躁狂症的疗效及安全性

Efficacy and Safety of Lithium Carbonate Combined with Clozapine in Treatment of Mania

目的:探讨碳酸锂与氯氮平联合治疗躁狂症的临床疗效及安全性。方法:选取2013年5月—2015年8月南阳市中心医院收治的躁狂症患者120例作为研究对象,以随机数字表法分为观察组和对照组各60例。对照组患者给予碳酸锂治疗,观察组患者给予碳酸锂与氯氮平联合治疗,2组患者均治疗8周。比较2组患者的治疗效果及不良反应发生情况。结果:治疗后,观察组患者的Bech-Rafaelsen躁狂量表、副反应量表评分均明显低于对照组,平均中位起效时间、症状缓解时间均明显短于对照组,血糖、血脂及体质量等指标均明显优于对照组,差异均有统计学意义(P<0.05)。结论:碳酸锂与氯氮平联合治疗躁狂症,疗效较好,不良反应较小,安全性较高,值得推广。

OBJECTIVE：To probe into the clinical efficacy and safety of lithium carbonate combined with clozapine in treatment of mania .METHODS：120 patients with mania admitted into Nanyang Central Hospital from May 2013 to Aug.2015 were selected to be divided into observation group and control group via the random number table , with 60 cases in each .The control group were treated with lithium carbonate , while the observation group received lithium carbonate combined with clozapine , the treatment course were 8 weeks.The treatment efficacy and adverse drug reactions were compared between two groups .RESUKTS： After treatment , in the observation group , the Bech-Rafaelsen mania rating scale and TESS scale score were significantly lower than those in the control group ;the average and median onset time, symptom alleviating time were significantly shorter than those in control group , and indicators as blood glucose , blood lipid and body mass were significantly better than those in control group , with statistically significant difference （ P〈0.05 ） .CONCLUSIONS： The efficacy of lithium carbonate combined with clozapine in treatment of mania is remarkable , with few adverse drug reactions and high safety .It is worthy of promotion and application .