阿托伐他汀联合鲑鱼降钙素、碳酸钙D_3、阿伦磷酸钠治疗老年骨质疏松症的疗效观察

Observation on Efficacy of Atorvastatin Combined with Salmon Calcitonin, Caltrate D3,Alendronate in Treatment of Senile Osteoporosis

目的:探讨阿托伐他汀联合鲑鱼降钙素、碳酸钙D3、阿伦磷酸钠治疗老年骨质疏松症患者临床疗效。方法:选取武汉科技大学附属天佑医院收治的老年骨质疏松症患者280例为研究对象,以随机数字表法分为观察组和对照组各140例。对照组患者给予碳酸钙D3联合阿伦磷酸钠,观察组在此基础上加用鲑鱼降钙素及阿托伐他汀治疗。比较2组疼痛视觉模拟评分情况、临床疗效,腰椎骨密度情况及不良反应发生情况。结果:2组患者治疗后疼痛视觉模拟评分均有明显下降,在相应时段观察组患者分值下降程度较对照组更明显,差异有统计学意义(P<0.05);观察组患者的总有效率为85.71%(120/140),对照组为68.57%(96/140),2组的差异有统计学意义(P<0.05);2组患者腰椎骨密度均较治疗前有明显增加,且观察组增加更明显,差异均有统计学意义(P<0.05)。结论:阿托伐他汀联合鲑鱼降钙素、碳酸钙D3、阿伦磷酸钠治疗老年骨质疏松症患者疗效确切,改善患者疼痛症状,提升骨密度水平,安全性较好。

OBJECTIVE：To probe into the clinical efficacy of atorvastatin combined with salmon calcitonin , caltrate D3 , alendronate in treatment of senile osteoporosis .METHODS：280 patients with senile osteoporosis admitted into Tianyou Hospital Affiliated to Wuhan University of Science and Technology were selected to be divided into observation group and control group via the random number table , with 140 cases in each .The control group were treated with caltrate D 3 combined with alendronate , and the observation group additionally received atorvastatin combined with salmon calcitonin based on the control group .The VAS score , clinical efficacy , BMD values and adverse drug reactions were compared between two group of patients .RESULTS： VAS score of two groups after treatment were significantly lower than those of before treatment , and those of the observation group were even lower than those the control group , with statistically significance （ P〈0.05 ） .The total efficacy in observation group was 85.71%（120/140）, significantly higher than that in control group 68.57%（96/140）, with statistically significant difference（P〈0.05）,lumbar bone mineral density of two groups after treatment were significantly more increased than those of before treatment , and the observation group was increased obviously ,with statistically significance （P〈0.05）. CONCLUSIONS：The efficacy of atorvastatin combined with salmon calcitonin , caltrate D3 , alendronate in treatment of senile osteoporosis is remarkable , which can improve bone density and relieve pain effectively with high safety .