270例药品不良反应报告

270 Cases of Adverse Drug Reaction Reports

目的:了解新汶矿业集团莱芜中心医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)的发生特点及规律,为临床合理用药提供参考。方法:对我院2015年收集并上报至国家ADR监测中心的270份ADR报告进行分析,分别从患者基本信息、药品用法与用量、药品系统归类、ADR表现形式、ADR报告类型以及关联性评价等方面进行汇总分。结果:我院270例ADR报告中,主要发生于40岁以上患者,占87.04%(235/270);ADR共涉及药品285种,其中以注射剂与粉针剂为主,占77.54%(221/285);引发ADR病例数排序居前10位的药品中,顺铂注射液居首位,抗菌药物有3种;ADR临床表现以皮肤及其附件损害为主(62例,占22.96%),其次为胃肠道损害(50例,占18.52%);新的ADR为68例(占25.19%),其中新的严重的ADR为28例(占10.37%),涉及药品主要为中药注射剂。结论:我院应进一步加强ADR监测工作,合理用药,以确保临床用药安全。

OBJECTIVE：To investigate the characteristics and laws of adverse drug reactions （ADR）in Xinwen Mining Group Laiwu Central Hospital（hereinafter referred to as “our hospital”）,so as to provide reference for the rational drug usein clinic.METHDS：270 cases of ADR reports collected and reported to National Center for ADR monitoring in 2015 werestatistically analyzed,in terms of the general information,dosage and usage,systematic classification of drugs,manifestation ofADR,report pattern of ADR and relevance evaluation,etc.RESULTS： Of the 270 cases in our hospital,patients over 40 yearsold were 87.04%（235/270）.285 kinds of drugs were involved,among which injection and powder-injection took the lead,accounting for 77.54%（221/285）.Of the top 10 ADR-inducing drugs,cisplatin injection dominated the first place,andhaving three kinds of antibacterial drugs.The clinical manifestations of ADR were mainly the lesion of skin and itsappendages （62 cases,22.96%）,followed by gastrointestinal system damage （50 cases,18.52%）.Meanwhile,68 cases（25.19%） were new ADR,and 28 cases （10.37%） were new and severe ADR,traditional Chinese medicine injections werethe main causes.CONCLUSIONS： Our hospital should strengthen the monitoring of ADR and promote the rational use ,so asto ensure the safe medication in clinic.