桂枝加龙骨牡蛎汤治疗高血压伴失眠症62例

Guizhi and Longgu Muli Decoction in the Treatment of Hypertension with Insomnia for 62 Cases

目的观察桂枝加龙骨牡蛎汤加味治疗高血压伴失眠症的临床疗效。方法将124例高血压伴失眠症的患者随机分为2组:治疗组和对照组。对照组给予氯硝西泮片,每晚2 mg,口服;治疗组在对照组的基础上,加用中药,每日1剂,分2次温服;2组治疗时间均为4周。在治疗结束和治疗结束4周时分别观察临床疗效、匹兹堡睡眠质量指数(PSQI)总分、血压。结果在治疗结束时,治疗组与对照组总有效率相当(P>0.05)、PSQI总分都下降明显(P<0.05),而在治疗结束后4周时,治疗组总有效率明显高于对照组(P<0.05)、PSQI总分下降较为明显(P<0.05);在治疗结束和治疗结束后4周时,2组都能明显降低患者的基线血压,其中治疗组更为明显(P<0.05)。结论桂枝加龙骨牡蛎汤联合西药治疗高血压伴失眠症疗效显著,另外,其在改善睡眠的同时可以协助降压,值得推广。

Objective To observe the clinical curative effect of modified Guizhi and Longgu Muli decoction in the treatment of hyper-tension with insomnia. Methods 124 cases of patients with hypertension with insomnia were randomized equally into the control group which were treated with clonazepam piece in a dose of 5mg each night and the treatment group which was given traditional Chinese medicine on the basis of the control group, a dose per day, which was divided into two parts, one part once in a proper tem-perature. The period of treatment was 4 weeks. Then the clinical curative effect, the score of Pittsburgh Sleep Quality Index（PSQI）, blood pressure at the end and after the end of the test were observed. Results At the end of the treatment, the total efficiency of the treatment group and the control group was roughly equal（ P〉0.05）, the score of PSQI decreased significantly（ P〈0.05）.After 4 weeks, the effective rate of the treatment group was significantly higher than that of the control group（ P〈0.05）, the score of PSQI of the treatment group dropped more obviously than that of the control group（ P〈0.05）, the blood pressure in the two observation period both decreased, while the treatment group obtained better effect（ P〈0.05）. Conclusion The modified Guizhi and Longgu Muli decoction in the treatment of hypertension with insomnia had significantly curative effect. Meanwhile, it could improve the sleep,and helps to reduce blood pressure. So, it is worth promoting.