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餐时和非餐时胰高血糖素样肽1受体激动剂的药理特点及临床应用 被引量:6

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摘要 胰高血糖素样肽1(GLP-1)受体激动剂(RA)是一类新型的肠促胰素类降糖药,通过皮下注射给药,可部分纠正2型糖尿病(T2DM)患者的GLP-1缺乏,以葡萄糖浓度依赖的方式刺激胰岛素分泌,减少胰高血糖素分泌,延迟胃排空,增加饱腹感,减少食物摄入。
作者 李焱
出处 《中华糖尿病杂志》 CAS CSCD 2016年第6期382-384,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
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  • 1Meier JJ. GI.P- 1 reeeptor agonists for individualized treatment of type 2 diabetes mellitus[J]. Nat Rev Endoerlnnl, 2012,8(12): 728-742. DOI: 10.103g/nrendo.2012.140.
  • 2Werner U, Haschke G, Herling AW, et al. Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes[J]. Regul Pept, 2010,164(2-3): 58-64. DOh 10.1016/j.regpep.2010.05.008.
  • 3Lorenz M, Pfeiffer C, Steinstrasser A, et al. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes--relationship to postprandial glycemia[J]. Regul Pept, 2013,185:1-8. DOh 10.1016/j.regpep.2013.04.001.
  • 4Meier JJ, Rosenstoek J, Hincelin-Mery A, et al. Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial[J]. Diabetes Care, 2015,38(7):1263-1273. DOI: 10.2337/de14-1984.
  • 5Kapitza C, Forst T, Coester H~, et al. Pharmacodynamie characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently contrnlled on mefformin[J]. Diabetes Obes Metab, 2013,15(7): 642-649. DOI: 10.111 l/dora.12076.
  • 6Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)[J]. Lancet, 2009,374(9683):39-47. DOI: 10.1016/ S0140-6736(09)60659-0.
  • 7Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Assoeiation and the European Association for the Study of Diabetes[J]. Diabetes Care, 2015,38(1):140-149. DOI: 10.2337/dcl 4-2441.
  • 8Fonseca VA, Alvarado-Ruiz R, Raccah D, et al. Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)[J]. Diabetes Care, 2012,35(6):1225-1231. DOI: 10.2337/ dcl 1-1935.
  • 9Rosenstock J, Racc, ah D, Korhnyi L, et al. Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X) [J]. Diabetes Care, 2013,36(10):2945-2951. DOI: 10.2337/ dc 12-2709.
  • 10Riddle MC, Forst T, Aronson R, et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: a 24-week, randomized, placebo-controlled study (GetGoal-Dun 1)[J], Diabetes Care, 2013,36(9):2497-2503. DOI: 10.2337/dcl 2-2462.

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