功能性消化不良患儿Hp治疗前后的症状及胃排空变化的超声观察

Gastric Emptying and Symptoms before and after Helicobacter Pylor Treatment in FD Patients

目的：探讨功能性消化不良患儿（Functional Dyspepsia,FD）幽门螺杆菌（Helicobacterpylori,Hp）治疗前后的症状及胃排空变化的超声观察。方法：选择我院6-10岁FD小儿患者70例为FD组,将其中28例Hp阴性者作为Hp阴性组,其余42例Hp阳性者作为治疗组。选取健康小儿72例作为对照组。超声测量入选者服用试餐即刻、20、40、60、90 min的近端、远端胃区面积,计算胃半排空时间。结果：FD组患儿上腹疼痛、上腹烧灼感、腹胀、恶心、嗳气和早饱症状的发生率均高于对照组,差异具有统计学意义（P〈0.05）;FD组近端、远端、全胃的半排空时间均较对照组慢,差异具有统计学意义（P〈0.05）。腹胀、嗳气和早饱是远端胃半排空延迟的危险因素（OR〉1,P〈0.05）;腹胀和上腹疼痛是全胃半排空延迟的危险因素（OR〉1,P〈0.05）。Hp阴性组、Hp治疗组近端、远端、全胃半排空时间较常规治疗组短,差异有统计学意义（P〈0.05）;Hp治疗组与Hp阴性组之间差异无统计学意义（P〉0.05）。结论：FD患儿的胃排空有所延迟,对Hp感染患儿进行Hp根治有助于消化不良症状的改善,在临床工作中可合理选择应用。

Objective： To investigate gastric emptying changes and symptoms before and after Helicobacter pylori （H. pylon） treatment in patients with functional dyspepsia （FD）. Methods： Seventy H. pylori patients aged 6~10 years from our hospital were selected and enrolled in this study as the H. pylori group （FD group）. Patients were divided into two groups： H. pylori-negative group （Hp-negative group, 28 patients）, and H. pylori-positive group （Hp-positive group, 42 patients）. 72 healthy children were selected as the control group. The proximal and distal stomach area was measured by ultrasound when patients took the test meal immediately, and at 20 min, 40 min, 60 min and 90 rain, and the gastric half-emptying time was calculated. Results： The incidence of epigastric pain, epigastric burning feeling, abdominal distension, nausea, belching and early satiety in the FD group was higher than that of the control group, and the difference was statistically significant （P〈0.05）; The proximal, distal and the whole gastric half-emptying time of the FD group were later than those of the control group, and the differences were statistically significant （P〈0.05）. The abdominal distension, belching and early satiety were the risk factors of the distal gastric half-emptying time （OR〉1, P〈0.05）. The abdominal distension and abdominal pain were risk factors of the whole gastric half-emptying time （OR〉1, P〈0.05）. The the proximal, distal, and whole of gastric half-emptying time in the Hp-negative and Hp-treatment groups were shorter than those of the conventional treatment group （P〈0.05）. There was no significant difference between the Hp treatment group and the Hp negative group （P〉0.05）. Conclusion： FD patients have delayed gastric emptying. H. pylori infection treatment helps to improve symptoms of dyspepsia and is a reasonable choice of application in clinical practice.