摘要
顶-底极性是上皮细胞的一项主要特征,参与细胞形态、迁移、功能维持等多个生物学事件。上皮细胞顶-底极性复合物包括PAR复合物、SCRIB复合物和CRB复合物。丧失极性是细胞癌化的标志之一,并且在人类癌症中也发现了顶-底极性复合物的异常表达。本文将就目前有关顶-底极性复合物在癌症方面的研究进行综述,重点阐述顶-底极性复合物在肿瘤发生、发展过程中的作用及调控机制。
As a main feature of epithelial cells, apico-basal polarity is involved in multiple biological processes including cell shape, migration and maintenance of cell function. Apico-basal polarity complexes contain three well-conserved members, namely, PAR, SCRIB and CRB. Loss of cell polarity is a hallmark for carcinoma, and deregulated or upregulated expression of apico-basal polartiy complex components has been well reported in a wide range of cancer types. This review will give an overview of the apico-basal polarity complexes and their close relationship with cancer.
出处
《现代生物医学进展》
CAS
2016年第20期3960-3964,3973,共6页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81272396
81470862)
国家重大科学研究计划(2013CB967103)
