VEGF基因多态性和ID2基因甲基化与法洛四联症发病机制的研究现状

Advance of the Pathogenesis about VEGF Gene Polymorphism and ID2 Gene Methylation with Tetralogy of Fallot

基因的多态性改变和甲基化表观遗传的修饰是有关法洛四联症在遗传学方面研究最多的发病机制,在心脏发育过程中VEGF基因的多态性和ID2基因甲基化的异常改变,可以导致这些基因的转录和表达调控的异常,使心脏发育缺陷而导致法洛四联症。通过对基因多态性和DNA甲基化的深入研究有助于法洛四联症发病机制的探讨,为疾病的诊断和治疗开辟新思路。

The change of Gene polymorphism and epigenetic modification of methylation was the most common pathogenesis about genetics of tetralogy of fallot. In the process of heart development, VEGF gene polymorphism and ID2 gene methylation can cause the heart developmental defect by abnormal regulation of these genes transcription and expression, leading to tetralogy of fallot. The fin-ther study of gene polymorphism and DNA methylation can help us to realize the pathogenesis of tetralogy of fallot and to get new ideas for its diagnosis and treatment.