摘要
目的探讨正清风痛宁联合美洛昔康治疗骨关节炎的临床疗效。方法选取2014年2月—2016年2月隆昌县人民医院收治的骨关节炎患者440例,根据治疗方案的不同分为对照组和治疗组,每组各220例。对照组口服美洛昔康分散片,1片/次,2次/d。治疗组在对照组治疗基础上口服正清风痛宁片,4片/次,3次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后WOMAC评分、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、软骨寡基质蛋白(COMP)及基质金属蛋白酶3(MMP-3)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为89.09%、95.45%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者疼痛评分、关节僵硬评分、日常活动评分、综合评分、IL-1β、TNF-α、COMP、MMP-3均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组的降低程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论正清风痛宁联合美洛昔康治疗骨关节炎具有较好的临床疗效,可明显改善患者的临床症状,降低血清炎性指标,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Zhengqing Fengtongning Tablets combined with meloxicam in treatment of osteoarthritis. Methods Patients(440 cases) with osteoarthritis in People's Hospital of Longchang County from February 2014 to February 2016 were divided into control group(220 cases) and treatment group(220 cases) according to different treatment plans. The patients in the control group were po administered with Meloxicam Dispersible Tablets, 1 tablet/time, twice daily. The patients in the treatment group were po administered with Zhengqing Fengtongning Tablets on the basis of the control group, 4 tablets/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of WOMAC scores, TNF-α, IL-1β, COMP, and MMP-3, two groups before and after treatment were compared. Results After treatment, the total efficacies in the control group and treatment group were 89.09% and 95.45%, respectively, and there were differences between two groups(P〈 0.05). After treatment, pain score, joint stiffness score, daily activity score, comprehensive score, IL-1β, TNF-α, COMP, and MMP-3 in two groups were significantly decreased, and the difference was statistically significant in the same group(P〈 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P〈 0.05). Conclusion Zhengqing Fengtongning Tablets combined with meloxicam has good clinical efficacy in treatment of osteoarthritis, and can obviously improve the clinical symptoms, and can reduce serum inflammatory indicators, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第6期830-833,共4页
Drugs & Clinic
关键词
正清风痛宁片
美洛昔康分散片
骨关节炎
WOMAC评分
Zhengqing Fengtongning Tablets
Meloxicam Dispersible Tablets
osteoarthritis
WOMAC scores