摘要
目的观察布拉酵母菌联合舒肝宁注射液治疗新生儿高胆红素血症的临床疗效。方法选取2014年6月—2015年6月在湖北医药学院附属人民医院进行治疗的新生儿高胆红素血症的患儿70例,随机分为对照组和治疗组,每组各35例。对照组患儿静脉滴注舒肝宁注射液,10 mL加入到10%葡萄糖注射液250 mL,1次/d,症状缓解后可改用肌内注射2 mL/次,1次/d。治疗组患儿在对照组的基础上给予布拉氏酵母菌散,1袋/次,1次/d。两组患儿均治疗2周。观察两组患儿的临床疗效,同时比较两组治疗前后胆红素水平和常见临床指标的变化。结果治疗后,对照组和治疗组的总有效率分别为80.00%、94.29%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿血清胆红素水平和经皮测定胆红素水平均显著下降,同组治疗前后差异比较具有统计学意义(P<0.05);且治疗后治疗组这些观察指标的下降幅度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患儿日均胆红素下降值明显大于对照组,而黄疸消退时间和蓝光治疗时间明显短于对照组,两组这些观察指标比较差异具有统计学意义(P<0.05)。结论布拉氏酵母菌联合舒肝宁注射液治疗新生儿高胆红素血症具有较好的临床疗效,可显著降低患儿体内胆红素水平,缩短黄疸消退时间及蓝光治疗时间,具有一定的临床推广应用价值。
Objective To explore the clinical effect of saccharomyces boulardii combined with Shuganning Injection in treatment of neonatal hyperbilirubinemia. Methods Children(70 cases) with neonatal hyperbilirubinemia in the Affiliated People's Hospital of Hubei Medical College from June 2014 to June 2015 were randomly divided into the control and treatment groups, and each group had 35 cases. Children in the control group were iv administered with Shuganning Injection, 10 mL added into 10% glucose injection 250 mL, once daily. And after symptomatic relief, iv administration could be replaced by im administration, 2 mL/time, once daily. Children in the treatment group were given with Saccharomyces Boulardii Sachets on the basis of the control group, 1 bag/time, once daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and bilirubin levels and common clinical indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 94.92%, respectively, and there were difference between two groups(P〈 0.05). After treatment, serum bilirubin levels and transcutaneous bilirubin levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P〈 0.05). And the observational indexes in the treatment were significantly lower than those in the control group, with significant difference between two groups(P〈 0.05). After treatment, bilirubin daily average decline in the treatment was significantly greater than that in the control group, but jaundice subsided time, and blue ray treatment time in the treatment group were obviously shorter than those in the control group, and the observational indexes were significant differences between two groups(P〈 0.05). Conclusion Saccharomyces boulardii combined with Shuganning Injection has clinical curative effect in treatment of neonatal hyperbilirubinemia, and can reduce bilirubin levels, shorten jaundice subsided time
出处
《现代药物与临床》
CAS
2016年第6期846-849,共4页
Drugs & Clinic