白藜芦醇治疗阿尔茨海默病的研究进展

Research progress on resveratrol in treatment of Alzheimer′s disease

神经退行性疾病是一种慢性进展性疾病,其特点是中枢神经系统神经元的逐渐丧失。由于血脑屏障的存在,经典的抗炎药物如类固醇激素和非甾体类抗炎药,对神经系统疾病的治疗作用有限。因此,开发新的抗炎药物,对于预防和治疗神经系统疾病具有重要的意义。白藜芦醇是一种有很强活性的天然多酚类物质,目前研究已显示其具有心血管保护、神经保护、免疫调节、肿瘤的化学预防作用。近年来还发现其具有抗神经炎症作用,可用于治疗神经精神性疾病,如帕金森病、阿尔茨海默病(AD)和亨廷顿症等。综述白藜芦醇对AD的保护作用及其机制研究进展,为进一步推进白藜芦醇用于防治AD的研究提供参考。

Neurodegenerative disease is a chronic progressive disease. Its characteristics is the gradual loss of the central nervous system neurons. Due to the presence of the blood-brain barrier, the classical anti-inflammatory drugs such as steroid hormones and non-steroid anti-inflammatory drugs are used in treatment of the nervous system diseases with a limited effect. Therefore, it is important to develop new anti-inflammatory drugs for prevention and treatment of nervous system diseases. Resveratrol is a kind of natural polyphenols with strong activity. At present, the study has shown that resveratrol has the functions of cardiovascular protection, neuroprotection, immunoregulation, and cancer chemopreventive effects. Recently, it has been found the function of resisting nerve inflammation, and is used in treatment of nervous system diseases such as Parkinson＇s disease, Alzheimer＇s disease（AD）, and Huntington＇s disease, etc. In order to provide reference for further promoting the research on resveratrol using to the prevention and treatment of AD, research progress on the protective effect and mechanism of resveratrol in treatment of AD is reviewed in this paper.