离子液体辅助合成磁性介孔炭微球及其对萘普生释放的影响

Ionic liquids assisted synthesis of magnetic mesoporous carbon microspheres and its effect on the release of naproxen

目的考察磁性介孔炭对萘普生的吸附与释放行为。方法通过简单的原位一锅法,以绿色溶剂离子液体辅助合成磁性介孔炭微球,通过N2吸附SEM、大角XRD和拉曼光谱对磁性介孔炭微球进行表征;并考察不同p H条件下,磁性介孔炭微球对萘普生释放的影响。结果随着Fe(NO3)3·9H2O用量的增大,磁性介孔炭微球的比表面积、孔径及孔容逐渐减小。磁性介孔炭微球大大提高了萘普生的释放速率,且累积释放率随着Fe-C的比表面积和孔容的增大而增大。在所研究的p H范围内(5.0,6.8,8.0),当p H=8.0时,萘普生在Fe-C-1上的载药量最高、释放最快,且累积释放速率最大。结论萘普生在磁性介孔炭微球上的释放分为3个阶段:第1阶段为中孔扩散,表面扩散过程占主导地位;第2阶段为孔隙扩散速率限制阶段,是萘普生被吸附进炭微球的内部毛孔后再逐渐释放的过程;第3阶段为释放平衡状态。

Objective To study the adsorption and release behavior of naproxen on carbon spheres. Methods Magnetic mesoporous carbon spheres were synthesized via a simple in-situ one pot method assisted by a green solvent ionic liquid. The magnetic mesoporous carbon spheres were characterized by N2 adsorption isotherms, SEM, wide-angle XRD and Raman spectra. The impact of pH value on the release rate of naproxen was estimated. Results The addition of Fe（ NO3 ）3 . 9H2O increased with the decrease of the specific surface area, pore diameter and pore volume of the materials. Within the pH range of this study （5.0,6.8,8.0）, Fe-C-1 exhibited the largest loading amount of naproxen, the fastest release rate and cumulative release rate at pH 8.0. Conclusions The cumulative release of naproxen in magnetic mesoporous carbon mierospheres could be split into three stages. The first stage was the mesopore diffusion, in which surface diffusion dominated the process. The second stage was the pore diffusion rate limiting stage, in which naproxen was adsorbed into the pores of carbon mierospheres, and then was gradually released. The last stage was the balance state of the drug release.