摘要
目的探讨蒽环类药物化疗对乳腺癌患者心肌损伤相关因素的影响。方法选取经手术治疗后辅以化疗的乳腺癌女性患者54例,分别在化疗前、化疗后1个月和2年检测超声心动图、肌钙蛋白Ⅰ（Ctn I）和脑钠肽前体（BNP）等因素的变化情况。结果在化疗前及化疗后不同期间,患者心率、血红蛋白未见明显变化。血浆BNP在患者发生心血管事件时明显升高,且随年龄增长（51~70岁）升高尤为显著（P〈0.05）。血浆Ctn I在化疗后1个月上升,2年后下降至化疗前水平。左室射血分数（LVEF）在患者化疗后1个月明显下降,且随年龄增长（51~70岁）降低。结论血浆BNP变化可作为临床监测蒽环类药物化疗后患者心功能损伤的一个重要指标。
Objective To study the effect of anthracycline chemotherapy on the related factors of myocardial injury in patients with breast cancer. Methods 54 cases of breast cancer patients treated with chemotherapy after surgery were selected. The changes of echocardiography, cardiac troponin I （CtnI） and brain natriuretic peptide （BNP） and other factors were detected before chemotherapy and 1 month and 2 years after chemotherapy. Results There was no significant change in heart rate and hemoglobin in patients before and after chemotherapy. Plasma BNP was significantly elevated in patients with cardiovascular events, and increased obviously with age （51-70 years） （P〈0.05）. Plasma CtnI increased 1 month after chemotherapy and decreased to pre-chemotherapy level after 2 years. LVEF decreased significantly in 1 month after chemotherapy, and decreased with age （51-70 years）. Conclusion Plasma BNP changes can be used as an important indicator of cardiac function in breast cancer patients undergoing anthracycline chemotherapy.
出处
《广东药学院学报》
CAS
2016年第3期383-386,共4页
Academic Journal of Guangdong College of Pharmacy
基金
广东省自筹经费类科技计划项目(粤科规财字【2015】110号)
