摘要
Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer, including helicobacter pylori infection, chronic inflammation, genetic factors et al. Among all of these, helicobacter pylori infection can significantly increase the production of reactive oxygen species（ROS） and reactive nitrogen species（RNS） in human stomach, which can cause the oxidative stress. Oxidative stress plays an important role in the pathogenesis of gastro-intestinal diseases such as mucosal damage, gastro-intestinal ulcers and cancer. Modern therapeutic treatments such as surgery and chemotherapy have undesired side effects, so the antioxidant therapy gains more and more attentions. Antioxidant therapy system comprises of various antioxidants（SOD, catalase, glutathione peroxidase and carnosine） and Chinese herbal medicine, which is mainly focused on the chemoprevention. Natural products and their derivatives, such as tea polyphenol, resveratrol and vitamins, have some potential benefits on their chemoprevention. Besides, much work has been done to understand the role of dietary factors playing in the prevention of gastrointestinal cancers. In this review based on some valuable studies, we aim to make some brief summaries about risk factors, pathogenic mechanism of oxidative stress and antioxidants therapy in gastric cancer.
胃癌是全球常见的恶性肿瘤之一,许多因素包括幽门螺杆菌感染、慢性炎症、遗传等均可导致胃癌。其中,幽门螺杆菌感染可显著增加活性氧(ROS)和活性氮(RNS)在胃中的产生,会导致氧化应激,而氧化应激是胃肠溃疡和癌症的重要发病机理。由于手术和化疗等治疗方法具有很大的副作用,抗氧化治疗受到越来越多的关注。抗氧化治疗系统主要包括各种抗氧化剂(超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和肌肽)和起预防作用的中草药,如茶多酚、白藜芦醇和维生素等。本文我们旨在对于胃癌相关的风险因素、氧化应激和抗氧化剂治疗的致病机理作出一些简短的总结。
基金
National Natural Science Foundation of China(Grant Nos.31471338,81260338)
