还原型谷胱甘肽钠治疗小儿急性感染性疾病致肝功能损害临床评价

Reduced Glutathione Sodium in the Treatment of Liver Function Damage Caused by Acute Infectious Diseases in Children

目的探讨还原型谷胱甘肽钠(GSH)治疗小儿急性感染性疾病致肝功能损害的临床疗效及安全性。方法选择急性感染性疾病致肝功能损害的患儿100例,随机分为观察组与对照组,各50例。其中对照组给予常规治疗,包括应用抗生素抗感染、护肝等,观察组在常规治疗的基础上给予GSH治疗,比较两组患儿治疗1周有效率,肝功能指标改善情况、恢复正常时间及并发症发生率。结果观察组患儿治疗有效率为98.00%,高于对照组的86.00%,差异有统计学意义(P<0.05);治疗后,观察组与对照组的丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)水平差异有统计学意义(P<0.05),观察组各指标改善明显,且观察组ALT,AST,γ-GT恢复正常水平时间较对照组短,差异均有统计学意义(P<0.05);观察组并发症发生率为8.00%(4/50),对照组为6.00%(3/50),差异无统计学意义(P>0.05)。结论应用GSH治疗小儿急性感染性疾病致肝功能损害,可有效提高治疗效果,缩短康复时间,安全性较高。

Objective To analyze the clinical efficacy and safety of reduced glutathione sodium （ GSH ） in the treatment of liver function damage caused by acute infectious diseases in children. Methods 100 cases of children with liver function damage caused by acute infectious diseases were randomly divided into observation group and control group, 50 cases in each group. The control group was given conventional treatment, including antibiotic resistant infection, liver protection and so on; the observation group was treated with GSH treatment on the basis of the routine treatment. The effective rates of the two groups of children after 1 week of treatment, index of liv-er function improvement, recovery time and the incidence of complications were compared. Results The effective rate of the observation group was 98. 00%, which was higher than 86. 00% of the control group, the difference was statistically significant （ P 〈 0. 05 ） . The ALT, AST and γ-GT in the observation group and the control group had significant difference after treatment （ P 〈 0. 05 ） , the observa-tion group was significantly improved, and the time of recovering to normal level in the observation group was shorter than the control group , the difference was statistically significant （ P 〈 0. 05 ） . The complication incidence rate of the observation group was 8. 00%（ 4 /50 ） , which had no significant difference with 6. 00% （ 3/50 ） of the control group （ P 〉 0. 05 ） . Conclusion GSH in the treatment of liver function damage in children caused by acute infectious disease can effectively improve the treatment effect, shorten the recovery time and has high security.