丹鹿通督片联合降钙素用于腰椎椎体终板骨软骨炎术后临床评价

Clinical Evaluation of Danlutongdu Pills Combined with Calcitonin for Postoperative Lumbar Vertebral Endplate Osteochondritis

目的观察丹鹿通督片联合降钙素对腰椎椎体终板骨软骨炎术后的临床疗效。方法将收治的腰椎椎体终板骨软骨炎术后患者102例随机分为对照组和治疗组,各51例。对照组给予降钙素注射治疗,治疗组在此基础上口服丹鹿通督片,2周为1个疗程,治疗3个疗程。观察并记录用药后两组患者腰痛症状的缓解程度,记录治疗后1,2,4,6周疼痛视觉模拟评分(VAS)、治疗起始及结束时1周内腰痛发生的频率和持续时间,同时记录治疗过程中出现的不良反应发生情况。结果与对照组比较,治疗后1,2,4,6周VAS评分降低(P<0.01),临床疗效显著(P<0.05),腰痛发作频率和持续时间降低(P<0.01),且未见明显不良反应发生。结论丹鹿通督片联合降钙素治疗腰椎椎体终板骨软骨炎能有效缓解术后疼痛的程度,减轻术后恢复期的腰痛程度,降低复发频率和发作持续时间,临床疗效显著,且不良反应少。

Objective To observe the clinical efficacy of Danlutongdu Pills combined with calcitonin in the treatment of postoperative lumbar vertebral endplate osteochondritis. Methods 102 patients hospitalized were randomly divided into the treatment group and the control group, 51 cases in each group. The control group was treated with calcitonin injection, and the treatment group was treated with Danlutongdu Pills combined with calcitonin. 2 weeks was 1 course of treatment, and treatment continued for 3 courses. The degree of lumbago symptom relief after medicine were recorded, and the VAS pain scores at 1, 2, 4, 6 weeks after treatment, the frequency and the duration of lumbago symptom were detected in the beginning and end of treatment, and the adverse reaction were also recorded. Results Compared with control group, the VAS pain scores at 1, 2, 4, 6 weeks after treatment was significantly decreased （ P 〈 0. 01 ） , the clinical effect between the two groups was statistically significant （ P 〈 0. 05 ） , the frequency and the duration of lumbago symptom were de-creased （ P 〈 0. 01 ） , both groups had less significant adverse reactions. Conclusion Danlutongdu Pills combined with calcitonin has ob-vious efficacy on the degree of lumbago symptom, and can decrease the degree of lumbago symptom in the recovery phase and reduce the frequency and the duration of lumbago symptom, with obvious clinical effect and few adverse reactions.