复合微孔多聚糖止血粉用于肺叶切除术的止血效果评价

Hemostatic Effect of Compound Microporous Polysaccharide Powder in Pulmonary Lobectomy

目的探讨复合微孔多聚糖止血粉在胸腔广泛致密粘连的肺叶切除术中的临床止血效果。方法选取2013年1月至2014年2月胸腔广泛致密粘连行肺叶切除术的患者58例,分为观察组和对照组,各29例。观察组采用复合微孔多聚糖止血粉进行局部止血,对照组采用常规止血。比较两组术后凝血功能、手术时间创面出血到止血的时间、术中出血量及术后第1天、第2天、第3天引流量及术后并发症情况。结果两组手术时间差异无统计学意义(P>0.05);观察组创面出血到止血的时间及术中出血量均小于对照组,差异有统计学意义(P<0.05);术后24 h两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)含量差异均无统计学意义(P>0.05);两组患者术后胸腔引流量逐日减少,各时间点观察组均低于对照组,差异有统计学意义(P<0.05)。结论复合微孔多聚糖止血粉应用于在胸腔广泛致密粘连的肺叶切除术中具有快速、有效、持久的止血效果。

Objective To study the hemostatic effect of compound microporous polysaccharide powder in pulmonary lobectomy with severe adhesion. Methods 58 cases of pulmonary lobectomy with severe adhesion from January 2013 to February 2014 were seleced and divided into the observation group （ using compound microporous polysaccharide powder, n=29 ） and the control group （ using routine hemostatic treatment, n=29 ） . The postoperative coagulation function, operation time, bleeding time, the amount of blood loss, the drainage of the first 3 postoperative-day, and postoperative complications were analyzed. Results There were no significant differences in opera-tion time, PT, APTT, TT and FIB between the two groups （ P 〉 0. 05 ）; the bleeding time and amount of blood loss of the observation group were lower than that of the control group （ P 〉 0. 05 ）; the drainage of the first 3 postoperative-day of the observation group were all lower than those of the control group （ P 〉 0. 05 ） . Conclusion Compound microporous polysaccharide powder for pulmonary lobectomy with severe adhesions is a fast and effective way to reduce intraoperative hemorrhage.